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dc.contributor.authorKhor, Yet H-
dc.contributor.authorSaravanan, Kirushallini-
dc.contributor.authorHolland, Anne E-
dc.contributor.authorLee, Joanna Y T-
dc.contributor.authorRyerson, Christopher J-
dc.contributor.authorMcDonald, Christine F-
dc.contributor.authorGoh, Nicole S L-
dc.identifier.citationScientific reports 2021; 11(1): 6874en
dc.description.abstractDyspnoea is a cardinal symptom of fibrotic interstitial lung disease (ILD), with a lack of proven effective therapies. With emerging evidence of the role of facial and nasal airflow for relieving breathlessness, this pilot study was conducted to examine the feasibility of conducting a clinical trial of a handheld fan (HHF) for dyspnoea management in patients with fibrotic ILD. In this mixed-methods, randomised, assessor-blinded, controlled trial, 30 participants with fibrotic ILD who were dyspnoeic with a modified Medical Research Council Dyspnoea grade ≥ 2 were randomised to a HHF for symptom control or no intervention for 2 weeks. Primary outcomes were trial feasibility, change in Dyspnoea-12 scores at Week 2, and participants' perspectives on using a HHF for dyspnoea management. Study recruitment was completed within nine months at a single site. Successful assessor blinding was achieved in the fan group [Bang's Blinding Index - 0.08 (95% CI - 0.45, 0.30)] but not the control group [0.47 (0.12, 0.81)]. There were no significant between-group differences for the change in Dyspnoea-12 or secondary efficacy outcomes. During qualitative interviews, participants reported that using the HHF relieved breathlessness and provided relaxation, despite initial scepticism about its therapeutic benefit. Oxygen-experienced participants described the HHF being easier to use, but not as effective for symptomatic relief, compared to oxygen therapy. Our results confirmed the feasibility of a clinical trial of a HHF in fibrotic ILD. There was a high level of patient acceptance of a HHF for managing dyspnoea, with patients reporting both symptomatic benefits and ease of use.en
dc.titleA mixed-methods pilot study of handheld fan for breathlessness in interstitial lung disease.en
dc.typeJournal Articleen
dc.identifier.journaltitleScientific reportsen
dc.identifier.affiliationDepartment of Medicine, University of British Columbia, Vancouver, BC, Canadaen
dc.identifier.affiliationDepartment of Allergy, Immunology and Respiratory Medicine, Monash University, Melbourne, Australiaen
dc.identifier.affiliationDepartment of Physiotherapy, Alfred Health, Melbourne, Australiaen
dc.identifier.affiliationCentre for Heart Lung Innovation, Providence Health Care, Vancouver, BC, Canadaen
dc.identifier.affiliationRespiratory and Sleep Medicineen
dc.identifier.affiliationInstitute for Breathing and Sleepen
dc.identifier.affiliationFaculty of Medicine, University of Melbourne, Melbourne, VIC, Australiaen
dc.identifier.affiliationDepartment of Respiratory Medicine, Alfred Health, Melbourne, Australiaen
dc.identifier.pubmedid33767311-, Nicole S L
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.openairecristype and Sleep Medicine- for Breathing and Sleep- (University of Melbourne)- for Breathing and Sleep- for Breathing and Sleep- and Sleep Medicine- and Sleep Medicine- for Breathing and Sleep-
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