Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/25999
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dc.contributor.authorDaniels, Christopher P-
dc.contributor.authorLiu, Howard Y-H-
dc.contributor.authorPorceddu, Sandro V-
dc.date.accessioned2021-03-09T05:05:00Z-
dc.date.available2021-03-09T05:05:00Z-
dc.date.issued2021-04-01-
dc.identifier.citationCurrent Opinion in Otolaryngology & Head and Neck Surgery 2021; 29(2): 100-106en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/25999-
dc.description.abstractTo provide a summary of the current evidence, with a focus on recent publications, pertaining to indications for postoperative radiation therapy for cutaneous squamous-cell carcinoma (cSCC), basal-cell carcinoma, Merkel-cell carcinoma and melanoma of the head and neck. Meta-analyses in cSCC and Merkel-cell carcinoma have shown an association between postoperative radiation therapy and overall survival. Prospective phase III data in head and neck cSCC has shown excellent locoregional control following surgery and postoperative radiation therapy. The addition of concurrent cytotoxic chemotherapy to postoperative radiation therapy has not improved outcomes in either of these two entities. Postoperative immune checkpoint inhibition or combined BRAF and MEK blockade in stage-III melanoma improves progression-free survival whereas postoperative radiation therapy does not. Further improvement in outcomes with high-risk cSCC and Merkel-cell carcinoma might be achieved with concurrent or sequential immune checkpoint inhibition and postoperative radiation therapy. Postoperative radiation therapy for cutaneous melanoma should be reserved for patients in whom novel systemic therapies are not a treatment option.en
dc.language.isoeng-
dc.titleIndications and limits of postoperative radiotherapy for skin malignancies.en
dc.typeJournal Articleen
dc.identifier.journaltitleCurrent Opinion in Otolaryngology & Head and Neck Surgeryen
dc.identifier.affiliationOlivia Newton-John Cancer Wellness and Research Centreen
dc.identifier.affiliationDepartment of Cancer Services, Princess Alexandra Hospital, Woolloongabbaen
dc.identifier.affiliationFaculty of Medicine, University of Queensland, St Lucia, Queensland, Australiaen
dc.identifier.doi10.1097/MOO.0000000000000696en
dc.type.contentTexten
dc.identifier.pubmedid33664195-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
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