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dc.contributor.authorPapapostolou, Stavroula-
dc.contributor.authorDinh, Diem T-
dc.contributor.authorNoaman, Samer-
dc.contributor.authorBiswas, Sinjini-
dc.contributor.authorDuffy, Stephen J-
dc.contributor.authorStub, Dion-
dc.contributor.authorShaw, James A-
dc.contributor.authorWalton, Antony-
dc.contributor.authorSharma, Anand-
dc.contributor.authorBrennan, Angela-
dc.contributor.authorClark, David J-
dc.contributor.authorFreeman, Melanie-
dc.contributor.authorYip, Thomas-
dc.contributor.authorAjani, Andrew-
dc.contributor.authorReid, Christopher M-
dc.contributor.authorOqueli, Ernesto-
dc.contributor.authorChan, William-
dc.identifier.citationHeart, Lung & Circulation 2021; 30(7): 1002-1013en
dc.description.abstractTo evaluate the effect of age in an all-comers population undergoing percutaneous coronary intervention (PCI). Age is an important consideration in determining appropriateness for invasive cardiac assessment and perceived clinical outcomes. We analysed data from 29,012 consecutive patients undergoing PCI in the Melbourne Interventional Group (MIG) registry between 2005 and 2017. 25,730 patients <80 year old (78% male, mean age 62±10 years; non-elderly cohort) were compared to 3,282 patients ≥80 year old (61% male, mean age 84±3 years; elderly cohort). The elderly cohort had greater prevalence of hypertension, diabetes and previous myocardial infarction (all p<0.001). Elderly patients were more likely to present with acute coronary syndromes, left ventricular ejection fraction <45% and chronic kidney disease (p<0.0001). In-hospital, 30-day and long-term all-cause mortality (over a median of 3.6 and 5.1 years for elderly and non-elderly cohorts, respectively) were higher in the elderly cohort (5.2% vs. 1.9%; 6.4% vs. 2.2%; and 43% vs. 14% respectively, all p<0.0001). In multivariate Cox regression analysis, estimated glomerular filtration rate (eGFR) <30 mL/min/1.73 m2 (HR 3.8, 95% CI: 3.4-4.3), cardiogenic shock (HR 3.0, 95% CI: 2.6-3.4), ejection fraction <30% (HR 2.5, 95% CI: 2.1-2.9); and age ≥80 years (HR 2.8, 95% CI: 2.6-3.1) were independent predictors of long-term all-cause mortality (all p<0.0001). The elderly cohort is a high-risk group of patients with increasing age being associated with poorer long-term mortality. Age, thus, should be an important consideration when individualising treatment in elderly patients.en
dc.subjectCoronary angiographyen
dc.subjectElderly octogenariansen
dc.subjectPercutaneous coronary interventionen
dc.titleEffect of Age on Clinical Outcomes in Elderly Patients (>80 Years) Undergoing Percutaneous Coronary Intervention: Insights From a Multi-Centre Australian PCI Registry.en
dc.typeJournal Articleen
dc.identifier.journaltitleHeart, Lung & Circulationen
dc.identifier.affiliationThe University of Melbourne, Parkville, VIC, Australiaen
dc.identifier.affiliationRoyal Melbourne Hospital, Melbourne VIC, Australiaen
dc.identifier.affiliationBallarat Base Hospital, Ballarat Central, VIC, Australiaen
dc.identifier.affiliationCurtin University, Perth, WA, Australiaen
dc.identifier.affiliationBarwon Health, Geelong, VIC, Australiaen
dc.identifier.affiliationEastern Health, Box Hill, VIC, Australiaen
dc.identifier.affiliationAustin Healthen
dc.identifier.affiliationCentre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne VIC, Australiaen
dc.identifier.affiliationAlfred Health, Melbourne VIC, Australiaen
dc.identifier.pubmedid33478864, David J
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.openairecristype of Melbourne Clinical School-
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