Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/25629
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DC Field | Value | Language |
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dc.contributor.author | Alemseged, Fana | - |
dc.contributor.author | Ng, Felix C | - |
dc.contributor.author | Williams, Cameron | - |
dc.contributor.author | Puetz, Volker | - |
dc.contributor.author | Boulouis, Gregoire | - |
dc.contributor.author | Kleinig, Timothy John | - |
dc.contributor.author | Rocco, Alessandro | - |
dc.contributor.author | Wu, Teddy Y | - |
dc.contributor.author | Shah, Darshan | - |
dc.contributor.author | Arba, Francesco | - |
dc.contributor.author | Kaiser, Daniel | - |
dc.contributor.author | Di Giuliano, Francesca | - |
dc.contributor.author | Morotti, Andrea | - |
dc.contributor.author | Sallustio, Fabrizio | - |
dc.contributor.author | Dewey, Helen M | - |
dc.contributor.author | Bailey, Peter | - |
dc.contributor.author | O'Brien, Billy | - |
dc.contributor.author | Sharma, Gagan | - |
dc.contributor.author | Bush, Steven | - |
dc.contributor.author | Dowling, Richard | - |
dc.contributor.author | Diomedi, Marina | - |
dc.contributor.author | Churilov, Leonid | - |
dc.contributor.author | Yan, Bernard | - |
dc.contributor.author | Parsons, Mark William | - |
dc.contributor.author | Davis, Stephen M | - |
dc.contributor.author | Mitchell, Peter J | - |
dc.contributor.author | Yassi, Nawaf | - |
dc.contributor.author | Campbell, Bruce C V | - |
dc.date | 2021-01-06 | - |
dc.date.accessioned | 2021-01-13T03:00:21Z | - |
dc.date.available | 2021-01-13T03:00:21Z | - |
dc.date.issued | 2021-01-06 | - |
dc.identifier.citation | Neurology 2021; online first: 6 January | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/25629 | - |
dc.description.abstract | To investigate the efficacy of tenecteplase (TNK), a genetically modified variant of alteplase with greater fibrin specificity and longer half-life than alteplase, prior to endovascular thrombectomy (EVT) in patients with basilar artery occlusion (BAO). To determine whether tenecteplase is associated with better reperfusion rates than alteplase prior to EVT in BAO, clinical and procedural data of consecutive BAO patients from the Basilar Artery Treatment and MANagement (BATMAN) registry and the Tenecteplase versus Alteplase before Endovascular Therapy for Ischemic Stroke (EXTEND-IA TNK) trial were retrospectively analyzed. Reperfusion >50% or absence of retrievable thrombus at the time of the initial angiogram was evaluated. RESULTS: We included 110 BAO patients treated with intravenous thrombolysis prior to EVT [mean age 69(SD 14); median NIHSS 16(IQR 7-32)]. Nineteen patients were thrombolysed with TNK (0.25mg/kg or 0.40mg/kg) and 91 with alteplase (0.9mg/kg). Reperfusion>50% occurred in 26% (n=5/19) of patients thrombolysed with TNK vs 7% (n=6/91) thrombolysed with alteplase (RR 4.0 95%CI 1.3-12; p=0.02), despite shorter thrombolysis-to-arterial-puncture time in the TNK-treated patients (48[IQR 40-71]mins) vs alteplase-treated patients (110[IQR 51-185]mins, p=0.004). No difference in symptomatic intracranial hemorrhage was observed (0/19(0%) TNK, 1/91(1%) alteplase, p=0.9). Tenecteplase may be associated with an increased rate of reperfusion in comparison with alteplase before EVT in BAO. Randomized controlled trials to compare tenecteplase with alteplase in BAO patients are warranted. This study provides Class III evidence that tenecteplase leads to higher reperfusion rates in comparison with alteplase prior to EVT in BAO patients. | en |
dc.language.iso | eng | |
dc.title | Tenecteplase Versus Alteplase Before Endovascular Therapy in Basilar Artery Occlusion. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Neurology | en |
dc.identifier.affiliation | Stroke Unit, University Hospital of Tor Vergata, Rome, Italy | en |
dc.identifier.affiliation | Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia | en |
dc.identifier.affiliation | Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia | en |
dc.identifier.affiliation | Department of Neurology and Dresden Neurovascular Center, University of Technology Dresden, Germany | en |
dc.identifier.affiliation | Department of Interventional Neuroradiology, Sainte-Anne -Hospital, Paris, France | en |
dc.identifier.affiliation | Stroke Unit, University Hospital of Tor Vergata, Rome, Italy | en |
dc.identifier.affiliation | Department of Neurology, Christchurch Hospital, Christchurch, New Zealand | en |
dc.identifier.affiliation | NEUROFARBA Department, Careggi University Hospital, Florence, Italy | en |
dc.identifier.affiliation | Institute of Neuroradiology and Dresden Neurovascular Center, University of Technology Dresden, Germany | en |
dc.identifier.affiliation | Department of Biomedicine and Prevention, University Hospital of Tor Vergata, Rome, Italy | en |
dc.identifier.affiliation | ASST Valcamonica, Department of Neurology, Esine, Italy | en |
dc.identifier.affiliation | Stroke Unit, University Hospital of Tor Vergata, Rome, Italy | en |
dc.identifier.affiliation | Neurology | en |
dc.identifier.affiliation | Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia | en |
dc.identifier.affiliation | Department of Radiology, Royal Melbourne Hospital, Parkville, Australia | en |
dc.identifier.affiliation | Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia | en |
dc.identifier.affiliation | Department of Neurology, Gosford Hospital, New South Wales, Australia | en |
dc.identifier.affiliation | Department of Neurology, Gold Coast University Hospital, Queensland, Australia | en |
dc.identifier.affiliation | Department of Neurosciences, Eastern Health, Melbourne, Australia | en |
dc.identifier.affiliation | Division of Medicine, Princess Alexandra Hospital, Brisbane, Australia | en |
dc.identifier.affiliation | Department of Neurology, Royal Adelaide Hospital, Adelaide, Australia | en |
dc.identifier.affiliation | Department of Radiology, Royal Melbourne Hospital, Parkville, Australia | en |
dc.identifier.doi | 10.1212/WNL.0000000000011520 | en |
dc.type.content | Text | en |
dc.identifier.orcid | 0000-0001-8422-9205 | en |
dc.identifier.orcid | 0000-0003-1845-1769 | en |
dc.identifier.orcid | 0000-0003-3941-7383 | en |
dc.identifier.orcid | 0000-0001-5258-0025 | en |
dc.identifier.orcid | 0000-0002-6067-183X | en |
dc.identifier.orcid | 0000-0002-6558-1155 | en |
dc.identifier.orcid | 0000-0001-9484-2070 | en |
dc.identifier.orcid | 0000-0003-3632-9433 | en |
dc.identifier.pubmedid | 33408145 | |
local.name.researcher | Churilov, Leonid | |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | Journal Article | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | Medicine (University of Melbourne) | - |
crisitem.author.dept | The Florey Institute of Neuroscience and Mental Health | - |
Appears in Collections: | Journal articles |
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