Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/25624
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dc.contributor.authorBalasubramanian, Adithya-
dc.contributor.authorOnggo, James-
dc.contributor.authorGunjur, Ashray-
dc.contributor.authorJohn, Thomas-
dc.contributor.authorParakh, Sagun-
dc.date2020-11-12-
dc.date.accessioned2021-01-13T03:00:20Z-
dc.date.available2021-01-13T03:00:20Z-
dc.date.issued2021-
dc.identifier.citationClinical lung cancer 2021; 22(2): 74-82en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/25624-
dc.description.abstractThe role of immune checkpoint inhibitors (ICIs) administered concurrently with or after definitive chemoradiation (CRT) in stage III non-small-cell lung cancer (NSCLC) has been detailed in several studies. We performed a systematic review to determine pneumonitis rates using ICIs with CRT. MEDLINE and EMBASE databases were searched using keywords and MeSH terms. Studies using anti-programmed cell death protein 1 (PD-1) or anti-programmed death-ligand 1 (PD-L1) therapy, either sequentially or concurrently with CRT, for patients with stage III NSCLC were included. A meta-analysis of pneumonitis rates was performed based on weighted pooled proportion, using random-effects models. Weighting was performed by the inverse variance or standard error of event rates. Comparative analysis between groups was performed. Odds ratios (OR) were used as the primary summary statistics. A total of 13 studies were identified (6 prospective clinical trials and 7 real-world reports). Rates of grade ≥ 3 pneumonitis were significantly higher in clinical trials using anti-PD-1 therapy compared with PD-L1 inhibitors (8.6%; 95% confidence interval [CI], 6.2%-11.9% vs. 4.4%; 95% CI, 3.0%-6.6%; OR, 2.0; P = .01). Clinical trials using concurrent ICI therapy with CRT had greater rates of grade 2 pneumonitis compared with sequential administration (23.0%; 95% CI, 15.8%-32.3% vs. 11.0%; 95% CI, 6.6%-17.8%; OR, 0.42; P = .02). Higher rates of grade ≥ 3 pneumonitis were observed in real-world studies compared with clinical trials involving sequential PD-L1 therapy (9.9%; 95% CI, 5.3%-17.9% vs. 4.4%; 95% CI, 2.9%-6.7%; OR, 0.43; P < .01). The suggestion of increased pneumonitis with a concurrent ICI strategy and using anti-PD-1 therapies warrants further consideration in future comparative studies.en
dc.language.isoeng-
dc.subjectDurvalumaben
dc.subjectImmunotherapyen
dc.subjectNSCLCen
dc.subjectPD-1 inhibitorsen
dc.subjectPD-L1 inhibitorsen
dc.titleImmune Checkpoint Inhibition With Chemoradiotherapy in Stage III Non-small-cell Lung Cancer: A Systematic Review and Meta-analysis of Safety Results.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical Lung Canceren
dc.identifier.affiliationSchool of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australiaen
dc.identifier.affiliationMedical Oncologyen
dc.identifier.affiliationOlivia Newton-John Cancer Research Instituteen
dc.identifier.affiliationDepartment of Medical Oncology, Monash Health, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Surgery, Eastern Health, Melbourne, Victoria, Australiaen
dc.identifier.doi10.1016/j.cllc.2020.10.023en
dc.type.contentTexten
dc.identifier.pubmedid33414053-
local.name.researcherBalasubramanian, Adithya
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.deptMedical Oncology-
crisitem.author.deptMedical Oncology-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
crisitem.author.deptMedical Oncology-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
crisitem.author.deptMedical Oncology-
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