A 2-Year Longitudinal Study of Physical Activity and Cardiovascular Risk in Survivors of Stroke.

Abstract

The purpose of this study was to explore associations between physical activity, cardiovascular risk factors, mobility, mood, fatigue and cognition over 2 years following stroke rehabilitation discharge. In this longitudinal observational study, survivors of first-ever stroke were evaluated at rehabilitation discharge, 6, 12, and 24 months later. Moderate to vigorous physical activity (MVPA) duration (minutes/day) assessed with an electronic monitor was the primary outcome. Further outcomes included step count, the number and duration of MVPA and sedentary bouts, cardiovascular risk factors (eg, blood pressure, fasting lipid profile, body mass index), gait speed and endurance, mood, fatigue, and cognition. Associations between physical activity and cardiovascular risk factors over time were assessed with random-effects regression modeling. Associations between baseline characteristics and physical activity at 2 years were explored using regression modeling. Seventy-nine participants (68.4% men) with a mean age of 65 years (SD = 14) and a median gait speed of 1.2 m/s (interquartile range = 0.8-1.4) were included at baseline. Associations were found between higher physical activity (MVPA duration, number and duration of MVPA bouts) and lower body mass index. Better gait speed, endurance, and cognition at baseline were associated with higher MVPA and step count at 2 years. Duration and bouts of MVPA are associated with body mass index. Increasing MVPA and bouts of MVPA may be a valuable treatment goal to reduce cardiovascular risk in survivors of stroke. This 2-year study found that moderate to vigorous physical activity is associated with important cardiovascular risk factors in people who have survived stroke. Understanding these associations could be useful for developing effective treatments to prevent recurrent stroke.