Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/25429
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dc.contributor.authorChin, Kai Sin-
dc.contributor.authorYassi, Nawaf-
dc.contributor.authorChurilov, Leonid-
dc.contributor.authorMasters, Colin Louis-
dc.contributor.authorWatson, Rosie-
dc.date2020-09-23-
dc.date.accessioned2020-12-06T21:53:54Z-
dc.date.available2020-12-06T21:53:54Z-
dc.date.issued2020-09-23-
dc.identifier.citationParkinsonism & Related Disorders 2020; 80: 184-193en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/25429-
dc.description.abstractAlzheimer's disease neuropathologies (amyloid-β and tau) frequently co-exist to varying degrees in Lewy body dementias (LBD), which include dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). To investigate the prevalence of tau in DLB and PDD, and its associations with clinical outcomes. We searched the major electronic databases using the search term: ("dementia with Lewy bodies" OR "diffuse Lewy body disease" OR "Lewy body variant of Alzheimer's disease") AND ("tau protein" OR "tauopathy" OR "neurofibrillary tangle"), for relevant studies which evaluated tau in LBD. Forty-nine articles met the inclusion criteria for data extraction. Where appropriate, a random-effect meta-analysis was performed to obtain pooled estimates for prevalence and risk ratios (RR) or standardized mean differences (SMD) for clinical features, diagnostic accuracy and cognition. Braak neurofibrillary tangle stage ≥ III was observed in 66% (n = 1511, 95%CI 60%-73%) of DLB and 52% (n = 433, 95%CI 27%-76%) of PDD at autopsy. Abnormal CSF phosphorylated-tau levels were present in 28% (n = 925, 95%CI 25%-31%) of DLB and 15% (n = 172, 95%CI 5%-24%) of PDD cases. Higher tau burden in DLB was associated with reduced likelihood of manifesting visual hallucinations (RR 0.56; 95%CI 0.40-0.77) and motor parkinsonism (RR 0.62; 95%CI 0.40-0.98), lower diagnostic accuracy of DLB during life (RR 0.49; 95%CI 0.38-0.64) and worse cognition prior to death (SMD 0.63; 95%CI 0.46-0.81). Tau is common in LBD and may reduce clinical diagnostic accuracy in people with DLB. Prospective longitudinal studies are needed to understand the roles of co-morbid neuropathologies in Lewy body dementias.en
dc.language.isoeng
dc.subjectAlzheimer's diseaseen
dc.subjectDementia with Lewy bodiesen
dc.subjectLewy body dementiaen
dc.subjectParkinson's disease dementiaen
dc.subjectTauen
dc.titlePrevalence and clinical associations of tau in Lewy body dementias: A systematic review and meta-analysis.en
dc.typeJournal Articleen
dc.identifier.journaltitleParkinsonism & Related Disordersen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3052, Australiaen
dc.identifier.affiliationDepartment of Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, 3050, Australiaen
dc.identifier.affiliationMedicine (University of Melbourne)en
dc.identifier.affiliationDepartment of Medicine - The Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, 3050, Australiaen
dc.identifier.affiliationPopulation Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australiaen
dc.identifier.doi10.1016/j.parkreldis.2020.09.030en
dc.type.contentTexten
dc.identifier.pubmedid33260030
local.name.researcherChurilov, Leonid
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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