Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/25290
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dc.contributor.authorCioccari, Luca-
dc.contributor.authorBitker, Laurent-
dc.contributor.authorToh, Lisa-
dc.contributor.authorHacking, Douglas-
dc.contributor.authorCutuli, Salvatore L-
dc.contributor.authorOsawa, Eduardo A-
dc.contributor.authorYanase, Fumitaka-
dc.contributor.authorNaorungroj, Thummaporn-
dc.contributor.authorLuethi, Nora-
dc.contributor.authorMichalopoulos, Adrian-
dc.contributor.authorWoo, Shanan-
dc.contributor.authorWang, Judy-
dc.contributor.authorEastwood, Glenn M-
dc.contributor.authorWeinberg, Laurence-
dc.contributor.authorBellomo, Rinaldo-
dc.date2020-11-11-
dc.date.accessioned2020-11-19T23:22:09Z-
dc.date.available2020-11-19T23:22:09Z-
dc.date.issued2020-11-11-
dc.identifier.citationEuropean Journal of Anaesthesiology 2020; online first: 11 Novemberen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/25290-
dc.description.abstractNear-infrared spectroscopy (NIRS) is used routinely to monitor cerebral tissue oxygen saturation (SctO2) during cardiopulmonary bypass (CPB) but is rarely employed outside the operating room. Previous studies indicate that patients are at risk of postoperative cerebral oxygen desaturation after cardiac surgery. We aimed to assess perioperative and postoperative changes in NIRS-derived SctO2 in cardiac surgery patients. Prospective observational study. The study was conducted in a tertiary referral university hospital in Australia from December 2017 to December 2018. We studied 34 adult patients (70.6% men) undergoing cardiac surgery requiring CPB and a reference group of 36 patients undergoing noncardiac surgical procedures under general anaesthesia. We measured SctO2 at baseline, during and after surgery, and then once daily until hospital discharge, for a maximum of 7 days. We used multivariate linear mixed-effects modelling to adjust for all relevant imbalances between the two groups. In the cardiac surgery group, SctO2 was 63.7% [95% confidence interval (CI), 62.0 to 65.5] at baseline and 61.0% (95% CI, 59.1 to 62.9, P = 0.01) on arrival in the ICU. From day 2 to day 7 after cardiac surgery, SctO2 progressively declined. At hospital discharge, SctO2 was significantly lower than baseline, at 53.5% (95% CI, 51.8 to 55.2, P < 0.001). In the reference group, postoperative SctO2 was not significantly different from baseline. On multivariable analysis, cardiac surgery, peripheral vascular disease and time since the operation were associated with greater cerebral desaturation, whereas higher haemoglobin concentrations were associated with slightly better cerebral oxygenation. After cardiac surgery on CPB, but not after noncardiac surgery, most patients experience prolonged cerebral desaturation. Such postoperative desaturation remained unresolved 7 days after surgery. The underlying mechanisms and time to resolution of such cerebral desaturations require further investigation.en
dc.language.isoeng
dc.titleProlonged postoperative cerebral oxygen desaturation after cardiac surgery: A prospective observational study.en
dc.typeJournal Articleen
dc.identifier.journaltitleEuropean Journal of Anaesthesiologyen
dc.identifier.affiliationIntensive Careen
dc.identifier.affiliationDepartment of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerlanden
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australiaen
dc.identifier.affiliationService de médecine intensive et réanimation, hôpital de la Croix Rousse, Hospices Civils de Lyon, Lyon, Franceen
dc.identifier.affiliationAnaesthesiaen
dc.identifier.affiliationDipartimento di Scienze dell'emergenza, anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A, Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italyen
dc.identifier.affiliationDepartment of Intensive Care, Siriraj Hospital, Mahidol University, Bangkok, Thailanden
dc.identifier.affiliationDepartment of Emergency Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerlanden
dc.identifier.affiliationSurgeryen
dc.identifier.affiliationSchool of Medicine, The University of Melbourneen
dc.identifier.affiliationData Analytics Research and Evaluation (DARE) Centreen
dc.identifier.doi10.1097/EJA.0000000000001391en
dc.type.contentTexten
dc.identifier.pubmedid33186311
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