Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/25158
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dc.contributor.authorYoung, Paul J-
dc.contributor.authorBailey, Michael-
dc.contributor.authorBellomo, Rinaldo-
dc.contributor.authorBernard, Stephen-
dc.contributor.authorBray, Janet-
dc.contributor.authorJakkula, Pekka-
dc.contributor.authorKuisma, Markku-
dc.contributor.authorMackle, Diane-
dc.contributor.authorMartin, Daniel-
dc.contributor.authorNolan, Jerry P-
dc.contributor.authorPanwar, Rakshit-
dc.contributor.authorReinikainen, Matti-
dc.contributor.authorSkrifvars, Markus B-
dc.contributor.authorThomas, Matt-
dc.date2020-10-12-
dc.date.accessioned2020-10-27T03:57:24Z-
dc.date.available2020-10-27T03:57:24Z-
dc.date.issued2020-12-
dc.identifier.citationResuscitation 2020; 157: 15-22en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/25158-
dc.description.abstractThe effect of conservative versus liberal oxygen therapy on mortality rates in post cardiac arrest patients is uncertain. We undertook an individual patient data meta-analysis of patients randomised in clinical trials to conservative or liberal oxygen therapy after a cardiac arrest. The primary end point was mortality at last follow-up. Individual level patient data were obtained from seven randomised clinical trials with a total of 429 trial participants included. Four trials enrolled patients in the pre-hospital period. Of these, two provided protocol-directed oxygen therapy for 60 min, one provided it until the patient was handed over to the emergency department staff, and one provided it for a total of 72 h or until the patient was extubated. Three trials enrolled patients after intensive care unit (ICU) admission and generally continued protocolised oxygen therapy for a longer period, often until ICU discharge. A total of 90 of 221 patients (40.7%) assigned to conservative oxygen therapy and 103 of 206 patients (50%) assigned to liberal oxygen therapy had died by this last point of follow-up; absolute difference; odds ratio (OR) adjusted for study only; 0.67; 95% CI 0.45 to 0.99; P = 0.045; adjusted OR, 0.58; 95% CI 0.35 to 0.96; P = 0.04. Conservative oxygen therapy was associated with a statistically significant reduction in mortality at last follow-up compared to liberal oxygen therapy but the certainty of available evidence was low or very low due to bias, imprecision, and indirectness. CRD42019138931.en
dc.language.isoeng-
dc.subjectCardiac arresten
dc.subjectHyperoxaemiaen
dc.subjectHypoxaemiaen
dc.subjectHypoxic ischaemic encephalopathyen
dc.subjectIndividual patient data meta-analysisen
dc.subjectOxygen therapyen
dc.subjectRandomised controlled trialen
dc.titleConservative or liberal oxygen therapy in adults after cardiac arrest: An individual-level patient data meta-analysis of randomised controlled trials.en
dc.typeJournal Articleen
dc.identifier.journaltitleResuscitationen
dc.identifier.affiliationMedical Research Institute of New Zealand, Wellington, New Zealand; Intensive Care Unit, Wellington Hospital, Wellington, New Zealanden
dc.identifier.affiliationInstitute of Clinical Medicine, University of Eastern Finland, Kuopio, Finlanden
dc.identifier.affiliationPeninsula Medical School, University of Plymouth, UKen
dc.identifier.affiliationDepartment of Anaesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finlanden
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationUniversity of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationIntensive Care Unit, John Hunter Hospital, New Lambton Heights, New South Wales, Australiaen
dc.identifier.affiliationSchool of Medicine and Public Health, University of Newcastle, Newcastle, Australiaen
dc.identifier.affiliationIntensive Care Unit, Royal Free Hospital, London, UKen
dc.identifier.affiliationWarwick Clinical Trials Unit, University of Warwick, Coventry, UKen
dc.identifier.affiliationConsultant in Anaesthesia and Intensive Care Medicine, Royal United Hospital, Bath, UKen
dc.identifier.affiliationDepartment of Epidemiology and Preventive Medicine, Monash University, Victoria, Australiaen
dc.identifier.affiliationIntensive Care Uniten
dc.identifier.affiliationDepartment of Perioperative, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Finlanden
dc.identifier.affiliationDepartment of Emergency Medicine, Helsinki University Hospital, Finlanden
dc.identifier.affiliationMedical Research Institute of New Zealand, Wellington, New Zealanden
dc.identifier.affiliationDepartment of Emergency Care and Services, University of Helsinki and Helsinki University Hospital, Finlanden
dc.identifier.affiliationIntensive Care Unit, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UKen
dc.identifier.affiliationCentre for Integrated Critical Care, University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.doi10.1016/j.resuscitation.2020.09.036en
dc.type.contentTexten
dc.identifier.pubmedid33058991-
local.name.researcherBellomo, Rinaldo
item.languageiso639-1en-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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