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https://ahro.austin.org.au/austinjspui/handle/1/25158
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DC Field | Value | Language |
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dc.contributor.author | Young, Paul J | - |
dc.contributor.author | Bailey, Michael | - |
dc.contributor.author | Bellomo, Rinaldo | - |
dc.contributor.author | Bernard, Stephen | - |
dc.contributor.author | Bray, Janet | - |
dc.contributor.author | Jakkula, Pekka | - |
dc.contributor.author | Kuisma, Markku | - |
dc.contributor.author | Mackle, Diane | - |
dc.contributor.author | Martin, Daniel | - |
dc.contributor.author | Nolan, Jerry P | - |
dc.contributor.author | Panwar, Rakshit | - |
dc.contributor.author | Reinikainen, Matti | - |
dc.contributor.author | Skrifvars, Markus B | - |
dc.contributor.author | Thomas, Matt | - |
dc.date | 2020-10-12 | - |
dc.date.accessioned | 2020-10-27T03:57:24Z | - |
dc.date.available | 2020-10-27T03:57:24Z | - |
dc.date.issued | 2020-12 | - |
dc.identifier.citation | Resuscitation 2020; 157: 15-22 | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/25158 | - |
dc.description.abstract | The effect of conservative versus liberal oxygen therapy on mortality rates in post cardiac arrest patients is uncertain. We undertook an individual patient data meta-analysis of patients randomised in clinical trials to conservative or liberal oxygen therapy after a cardiac arrest. The primary end point was mortality at last follow-up. Individual level patient data were obtained from seven randomised clinical trials with a total of 429 trial participants included. Four trials enrolled patients in the pre-hospital period. Of these, two provided protocol-directed oxygen therapy for 60 min, one provided it until the patient was handed over to the emergency department staff, and one provided it for a total of 72 h or until the patient was extubated. Three trials enrolled patients after intensive care unit (ICU) admission and generally continued protocolised oxygen therapy for a longer period, often until ICU discharge. A total of 90 of 221 patients (40.7%) assigned to conservative oxygen therapy and 103 of 206 patients (50%) assigned to liberal oxygen therapy had died by this last point of follow-up; absolute difference; odds ratio (OR) adjusted for study only; 0.67; 95% CI 0.45 to 0.99; P = 0.045; adjusted OR, 0.58; 95% CI 0.35 to 0.96; P = 0.04. Conservative oxygen therapy was associated with a statistically significant reduction in mortality at last follow-up compared to liberal oxygen therapy but the certainty of available evidence was low or very low due to bias, imprecision, and indirectness. CRD42019138931. | en |
dc.language.iso | eng | - |
dc.subject | Cardiac arrest | en |
dc.subject | Hyperoxaemia | en |
dc.subject | Hypoxaemia | en |
dc.subject | Hypoxic ischaemic encephalopathy | en |
dc.subject | Individual patient data meta-analysis | en |
dc.subject | Oxygen therapy | en |
dc.subject | Randomised controlled trial | en |
dc.title | Conservative or liberal oxygen therapy in adults after cardiac arrest: An individual-level patient data meta-analysis of randomised controlled trials. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Resuscitation | en |
dc.identifier.affiliation | Medical Research Institute of New Zealand, Wellington, New Zealand; Intensive Care Unit, Wellington Hospital, Wellington, New Zealand | en |
dc.identifier.affiliation | Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland | en |
dc.identifier.affiliation | Peninsula Medical School, University of Plymouth, UK | en |
dc.identifier.affiliation | Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland | en |
dc.identifier.affiliation | Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia | en |
dc.identifier.affiliation | University of Melbourne, Parkville, Victoria, Australia | en |
dc.identifier.affiliation | Intensive Care Unit, John Hunter Hospital, New Lambton Heights, New South Wales, Australia | en |
dc.identifier.affiliation | School of Medicine and Public Health, University of Newcastle, Newcastle, Australia | en |
dc.identifier.affiliation | Intensive Care Unit, Royal Free Hospital, London, UK | en |
dc.identifier.affiliation | Warwick Clinical Trials Unit, University of Warwick, Coventry, UK | en |
dc.identifier.affiliation | Consultant in Anaesthesia and Intensive Care Medicine, Royal United Hospital, Bath, UK | en |
dc.identifier.affiliation | Department of Epidemiology and Preventive Medicine, Monash University, Victoria, Australia | en |
dc.identifier.affiliation | Intensive Care Unit | en |
dc.identifier.affiliation | Department of Perioperative, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Finland | en |
dc.identifier.affiliation | Department of Emergency Medicine, Helsinki University Hospital, Finland | en |
dc.identifier.affiliation | Medical Research Institute of New Zealand, Wellington, New Zealand | en |
dc.identifier.affiliation | Department of Emergency Care and Services, University of Helsinki and Helsinki University Hospital, Finland | en |
dc.identifier.affiliation | Intensive Care Unit, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK | en |
dc.identifier.affiliation | Centre for Integrated Critical Care, University of Melbourne, Parkville, Victoria, Australia | en |
dc.identifier.doi | 10.1016/j.resuscitation.2020.09.036 | en |
dc.type.content | Text | en |
dc.identifier.pubmedid | 33058991 | - |
local.name.researcher | Bellomo, Rinaldo | |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Intensive Care | - |
crisitem.author.dept | Data Analytics Research and Evaluation (DARE) Centre | - |
Appears in Collections: | Journal articles |
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