Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/25061
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dc.contributor.authorJeffrey, Angus W-
dc.contributor.authorJeffrey, Gary P-
dc.contributor.authorStormon, Michael-
dc.contributor.authorThomas, Gordon-
dc.contributor.authorO'Loughlin, Edward-
dc.contributor.authorShun, Albert-
dc.contributor.authorHardikar, Winita-
dc.contributor.authorJones, Robert M-
dc.contributor.authorMcCall, John-
dc.contributor.authorEvans, Helen-
dc.contributor.authorStarkey, Graham M-
dc.contributor.authorHodgkinson, Peter-
dc.contributor.authorEe, Looi C-
dc.contributor.authorMoore, David-
dc.contributor.authorMews, Catherine-
dc.contributor.authorMcCaughan, Geoff W-
dc.contributor.authorAngus, Peter W-
dc.contributor.authorWigg, Alan J-
dc.contributor.authorCrawford, Michael-
dc.contributor.authorFawcett, Jonathan-
dc.date2020-10-04-
dc.date.accessioned2020-10-15T03:16:46Z-
dc.date.available2020-10-15T03:16:46Z-
dc.date.issued2020-11-
dc.identifier.citationMedical Journal of Australia 2020; 213(1): 464-470en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/25061-
dc.description.abstractTo assess long term graft and patient survival after donor liver retransplantation in children in Australia and New Zealand during 1986-2017; to determine the factors that influence survival. Retrospective cohort analysis (registry data). Australia and New Zealand Liver Transplant Registry data for all liver retransplantations in children (under 18 years of age), 1986-2017, in all four paediatric and six adult liver transplantation centres in the two countries. Graft and patient survival at one, 5, 10 and 15 years. 142 liver retransplantations were undertaken in children (59 during 1986-2000, 83 during 2001-2017). Kaplan-Meier survival analysis indicated that survival was significantly greater during 2001-2017 than 1986-2000 (P < 0.001). During 2001-2017, graft survival one year after retransplantation was 84%, at 5 years 75%, at 10 years 70%, and at 15 years 54%; patient survival was 89% at one year, 87% at 5 years, 87% at 10 years, and 71% at 15 years. Median time between transplantations was 0.2 years (IQR, 0.03-1.4 years) during 1986-2000, and 1.8 years (IQR, 0.1-6.8 years) during 2001-2017 (P = 0.002). The proportion of graft failures that involved split grafts was larger during 2001-2017 (35 of 83, 42%) than 1986-2000 (10 of 59, 17%). Graft type, cause of graft failure, and number of transplants did not influence survival following retransplantation. Survival for children following retransplantation is excellent. Graft survival is similar for split and whole grafts. Children on the liver waiting list requiring retransplantation should have the same access to donor grafts as children requiring a first transplant.en
dc.language.isoeng
dc.subjectEthicsen
dc.subjectLiver diseasesen
dc.subjectLiver transplantationen
dc.subjectTissue and organ procurementen
dc.titleOutcomes for children after second liver transplantations are similar to those after first transplantations: a binational registry analysis.en
dc.typeJournal Articleen
dc.identifier.journaltitleMedical Journal of Australiaen
dc.identifier.affiliationSir Charles Gairdner Hospital, Perth, WAen
dc.identifier.affiliationThe University of Western Australia, Perth, WAen
dc.identifier.affiliationThe University of Sydney, Sydney, NSWen
dc.identifier.affiliationSydney Medical School, , the University of Sydney, Sydney, NSWen
dc.identifier.affiliationAustralian National Liver Transplantation Unit, Royal Prince Alfred Hospital, Sydney, NSWen
dc.identifier.affiliationStarship Children's Health, Auckland, New Zealanden
dc.identifier.affiliationNew Zealand Liver Transplant Unit, Auckland City Hospital, Auckland, New Zealanden
dc.identifier.affiliationVictorian Liver Transplant Unit, Royal Children's Hospital, Melbourne, VICen
dc.identifier.affiliationVictorian Liver Transplant Uniten
dc.identifier.affiliationThe University of Sydney, Sydney, NSWen
dc.identifier.affiliationAustralian National Liver Transplantation Service, Children's Hospital at Westmead, Sydney, NSWen
dc.identifier.affiliationSir Charles Gairdner Hospital, Perth, WAen
dc.identifier.affiliationThe University of Queensland, Brisbane, QLDen
dc.identifier.affiliationQueensland Liver Transplantation Service, Princess Alexandra Hospital, Brisbane, QLDen
dc.identifier.affiliationAustralian National Liver Transplantation Unit, Royal Prince Alfred Hospital, Sydney, NSWen
dc.identifier.affiliationRoyal Children's Hospital, Melbourne, VICen
dc.identifier.affiliationStarship Children's Health, Auckland, New Zealanden
dc.identifier.affiliationLady Cilento Children's Hospital, Brisbane, QLDen
dc.identifier.affiliationWomen's and Children's Hospital, Adelaide, SAen
dc.identifier.affiliationPerth Children's Hospital, Perth, WAen
dc.identifier.affiliationSouth Australian Liver Transplantation Service, Flinders Medical Centre, Adelaide, SAen
dc.identifier.doi10.5694/mja2.50802en
dc.type.contentTexten
dc.identifier.orcid0000-0002-9137-0204en
dc.identifier.pubmedid33015834
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