Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/25034
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dc.contributor.authorKramer, Sharon F-
dc.contributor.authorCumming, Toby B-
dc.contributor.authorJohnson, Liam G-
dc.contributor.authorChurilov, Leonid-
dc.contributor.authorBernhardt, Julie-
dc.date2020-10-09-
dc.date.accessioned2020-10-15T03:15:14Z-
dc.date.available2020-10-15T03:15:14Z-
dc.date.issued2020-10-09-
dc.identifier.citationJournal of Stroke and Cerebrovascular Diseases 2020; 29(12): 105359en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/25034-
dc.description.abstractThere is strong evidence that cardiorespiratory fitness (CRF) training improves fitness and mobility after stroke. Despite the large number of studies, the most efficacious dose is yet to be determined. Furthermore, the safety of early post-stroke training, while theoretically beneficial, remains uncertain. The aim of this study is to determine the maximum safe and tolerable intensity of CRF training early post-stroke. This is a stratified (low to moderate exercise capacity), Phase I, 5+5 dose ranging trial protocol. Participants will be recruited within one month post-stroke and stratified by their exercise-capacity (i.e. low and moderate capacity). Cohorts of five participants will perform 12 interval-based training sessions for four-weeks at a pre-determined target-intensity. The intensity will increase in each consecutive cohort, in each stratum according to pre-defined rules until the maximum safe and tolerable intensity is reached, as determined by the occurrence of dose-limiting events and occurrence of adverse events. Dose-limiting events are defined as symptoms indicative of over-training including pain and inability to perform usual activities. Maximum safe and tolerable intensity of CRF training in stroke survivors with low and moderate exercise capacity. This study is a first step in the systematic development of a CRF training intervention. We believe similar dose ranging designs may be useful for development of other rehabilitation interventions in different study populations.en
dc.language.isoeng
dc.subjectCardiorespiratory trainingen
dc.subjectDose rangingen
dc.subjectExerciseen
dc.subjectPhysical fitnessen
dc.subjectStrokeen
dc.titleDetermining Maximal Tolerable Aerobic Training Intensity in the Acute Phase after Stroke: a Novel Dose Ranging Trial Protocol.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Stroke and Cerebrovascular Diseasesen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Healthen
dc.identifier.affiliationNHMRC Centre of Research Excellence in Stroke Rehabilitation and Brain Recovery, 245 Burgundy Street, 3084, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationSchool of Health Sciences, Australian Catholic University, 115 Victoria Parade, 3065 Melbourne, Victoria, Australiaen
dc.identifier.affiliationMelbourne Medical School, University of Melbourne, 245 Burgundy Street, 3084, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1016/j.jstrokecerebrovasdis.2020.105359en
dc.type.contentTexten
dc.identifier.pubmedid33045625
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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