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dc.contributor.authorPua, Emmanuel Peng Kiat-
dc.contributor.authorThomson, Phoebe-
dc.contributor.authorYang, Joseph Yuan-Mou-
dc.contributor.authorCraig, Jeffrey M-
dc.contributor.authorBall, Gareth-
dc.contributor.authorSeal, Marc-
dc.identifier.citationCerebral cortex 2021; 31(1): 681-693en
dc.description.abstractThe neurobiology of heterogeneous neurodevelopmental disorders such as Autism Spectrum Disorders (ASD) is still unknown. We hypothesized that differences in subject-level properties of intrinsic brain networks were important features that could predict individual variation in ASD symptom severity. We matched cases and controls from a large multicohort ASD dataset (ABIDE-II) on age, sex, IQ, and image acquisition site. Subjects were matched at the individual level (rather than at group level) to improve homogeneity within matched case-control pairs (ASD: n = 100, mean age = 11.43 years, IQ = 110.58; controls: n = 100, mean age = 11.43 years, IQ = 110.70). Using task-free functional magnetic resonance imaging, we extracted intrinsic functional brain networks using projective non-negative matrix factorization. Intrapair differences in strength in subnetworks related to the salience network (SN) and the occipital-temporal face perception network were robustly associated with individual differences in social impairment severity (T = 2.206, P = 0.0301). Findings were further replicated and validated in an independent validation cohort of monozygotic twins (n = 12; 3 pairs concordant and 3 pairs discordant for ASD). Individual differences in the SN and face-perception network are centrally implicated in the neural mechanisms of social deficits related to ASD.en
dc.subjectautism spectrum disordersen
dc.subjectintrinsic brain networksen
dc.subjectneural correlatesen
dc.titleIndividual Differences in Intrinsic Brain Networks Predict Symptom Severity in Autism Spectrum Disorders.en
dc.typeJournal Articleen
dc.identifier.journaltitleCerebral Cortexen
dc.identifier.affiliationDepartment of Paediatrics, University of Melbourne, Parkville VIC 3010, Australiaen
dc.identifier.affiliationMelbourne School of Psychological Sciences, University of Melbourne, Parkville VIC 3010, Australiaen
dc.identifier.affiliationCentre for Molecular and Medical Research, School of Medicine, Deakin University, Geelong VIC 3220, Australiaen
dc.identifier.affiliationMolecular Epidemiology, Murdoch Children's Research Institute, Parkville VIC 3052, Australiaen
dc.identifier.affiliationDepartment of Neurosurgery, Neuroscience Advanced Clinical Imaging Suite (NACIS), The Royal Children's Hospital, Parkville VIC 3052, Australiaen
dc.identifier.affiliationNeuroscience Research, Murdoch Children's Research Institute, Parkville VIC 3052, Australiaen
dc.identifier.affiliationMedicine (University of Melbourne)en
dc.identifier.affiliationDevelopmental Imaging, Murdoch Children's Research Institute, Parkville VIC 3052, Australiaen
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item.openairetypeJournal Article-
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