Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/24929
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Heron, Vanessa C | - |
dc.contributor.author | Kerr, Peter G | - |
dc.contributor.author | Kanellis, John | - |
dc.contributor.author | Polkinghorne, Kevan R | - |
dc.contributor.author | Isbel, Nikky M | - |
dc.contributor.author | See, Emily J | - |
dc.date | 2020-09-24 | - |
dc.date.accessioned | 2020-10-02T03:26:53Z | - |
dc.date.available | 2020-10-02T03:26:53Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.citation | Transplantation Proceedings 2021; 53(3): 839-847 | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/24929 | - |
dc.description.abstract | End-stage kidney disease secondary to hyperoxaluria presents a major challenge for transplant physicians given concern regarding disease recurrence. Few contemporary studies have reported long-term outcomes following transplantation in this population. This study examined the outcomes of all adult patients with end-stage kidney disease secondary to hyperoxaluria who received a kidney or combined liver-kidney transplant in Australia and New Zealand between 1965 and 2015. Patients with hyperoxaluria were propensity score matched to control patients with reflux nephropathy. The primary outcome was graft survival. Secondary outcomes included graft function, acute rejection, and patient survival. Nineteen transplants performed in 16 patients with hyperoxaluria were matched to 57 transplants in patients with reflux nephropathy. Graft survival was inferior in patients with hyperoxaluria receiving a kidney transplant alone (subhazard ratio [SHR] = 3.83, 95% confidence interval [CI], 1.22-12.08, P = .02) but not in those receiving a combined liver-kidney transplant (SHR = 0.63, 95% CI, 0.08-5.21, P = .67). Graft failure risk was particularly high in patients with hyperoxaluria receiving a kidney transplant alone after more than 1 year of renal replacement therapy (SHR = 8.90, 95% CI, 2.35-33.76, P = .001). Posttransplant estimated glomerular filtration rate was lower in patients with hyperoxaluria (10.97 mL/min/1.73 m2, 95% CI, 0.53-21.42, P = .04). There was no difference between groups in the risk of acute rejection or death with a functioning graft. Compared to reflux nephropathy, hyperoxaluria was associated with inferior graft survival in patients receiving a kidney transplant alone. Long-term graft function was lower in patients with hyperoxaluria, but the risks of acute rejection and death were not different. | en |
dc.language.iso | eng | - |
dc.title | Long-Term Graft and Patient Outcomes Following Kidney Transplantation in End-Stage Kidney Disease Secondary to Hyperoxaluria. | en |
dc.type | Journal Article | en_US |
dc.identifier.journaltitle | Transplantation Proceedings | en |
dc.identifier.affiliation | Department of Nephrology, Monash Health, Clayton, Victoria, Australia | en |
dc.identifier.affiliation | Nephrology | en |
dc.identifier.affiliation | Center for Inflammatory Diseases, Department of Medicine, Monash University, Clayton, Victoria, Australia | en |
dc.identifier.affiliation | Department of Nephrology, Princess Alexandra Hospital, Brisbane, Queensland, Australia | en |
dc.identifier.affiliation | Intensive Care | en |
dc.identifier.affiliation | School of Medicine, University of Melbourne, Parkville, Victoria, Australia | en |
dc.identifier.affiliation | Department of Epidemiology and Preventative Medicine, Monash University, Clayton, Victoria, Australia | en |
dc.identifier.doi | 10.1016/j.transproceed.2020.08.028 | en |
dc.type.content | Text | en_US |
dc.identifier.pubmedid | 32980135 | - |
local.name.researcher | Heron, Vanessa C | |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | Nephrology | - |
crisitem.author.dept | Intensive Care | - |
Appears in Collections: | Journal articles |
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.