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dc.contributor.authorFraser, Jacqueline-
dc.contributor.authorMousley, Johanna-
dc.contributor.authorTestro, Adam G-
dc.contributor.authorSmibert, Olivia C-
dc.contributor.authorKoshy, Anoop N-
dc.identifier.citationTransplantation Proceedings 2020; 52(9): 2676-2683en
dc.description.abstractLiver transplant recipients may be at increased risk for adverse outcomes with coronavirus disease 2019 (COVID-19) infection because of chronic immunosuppression and associated comorbidities. There is a paucity of literature describing clinical presentation, treatments, and outcomes in liver transplant recipients with COVID-19. A systematic search was performed for articles published up to June 15, 2020, revealing 223 liver transplant recipients with COVID-19 in 15 studies. Patients most commonly presented with fever (66.7%), dyspnea (34.0%), and diarrhea (28.4%). Of these, 77.7% required hospitalization, 24% had mild disease, 40% had moderate disease, and 36% had severe disease. Immunosuppression was modified in 32.8% of recipients. The case fatality rate was 19.3%. Dyspnea on presentation, diabetes mellitus, and age 60 years or older were significantly associated with increased mortality (P ≤ .01) with a trend to higher mortality rate observed in those with hypertension and those receiving corticosteroids at the time of COVID-19 diagnosis. The median time from symptoms to death was 11.5 days (2-45 days). In conclusion, liver transplant recipients with severe acute respiratory syndrome coronavirus 2 are overrepresented with regard to severe disease and hospitalizations. Older liver transplant patients with diabetes mellitus or hypertension, who are on maintenance corticosteroids, with a diagnosis of COVID-19 and describing breathlessness should be aggressively monitored for signs of deterioration because of the risk for mortality.en
dc.titleClinical Presentation, Treatment, and Mortality Rate in Liver Transplant Recipients With Coronavirus Disease 2019: A Systematic Review and Quantitative Analysis.en
dc.typeJournal Articleen
dc.identifier.journaltitleTransplantation Proceedingsen
dc.identifier.affiliationGastroenterology and Hepatologyen
dc.identifier.affiliationVictorian Liver Transplant Uniten
dc.identifier.affiliationThe University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationInfectious Diseasesen
dc.identifier.affiliationThe National Centre for Infections in Cancer, Peter McCallum Cancer Centre, Melbourne, VIC, Australiaen
dc.identifier.affiliationDeakin University, School of Medicine, Geelong, Victoria, Australiaen
dc.identifier.pubmedid32891405-, Jacqueline
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.grantfulltextnone- Liver Transplant Unit- and Hepatology- Liver Transplant Unit- and Hepatology- Diseases-
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