Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/24581
Full metadata record
DC FieldValueLanguage
dc.contributor.authorRussell, Hollie-
dc.contributor.authorChurilov, Leonid-
dc.contributor.authorToh, Lisa-
dc.contributor.authorEastwood, Glenn M-
dc.contributor.authorBellomo, Rinaldo-
dc.date2019-09-15-
dc.date.accessioned2020-09-28T20:42:22Z-
dc.date.available2020-09-28T20:42:22Z-
dc.date.issued2019-12-
dc.identifier.citationJournal of Critical Care 2019; 54: 244-249en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/24581-
dc.description.abstractTo study the incidence, predictors and outcomes of QTc prolongation (≥500 ms) during ICU admission. Prospective observational study of patients admitted to a tertiary ICU during a two-month period. We obtained daily data on QTc intervals and arrhythmias from ICU monitors. We performed univariate and multivariable analyses to compare patients who did or did not experience QTc prolongation. Of the 257 patients, 93 (36.2%) developed ≥1 episode of QTc ≥500 ms. Such patients had higher APACHE II scores (p < .001), received more QT-prolonging medications (p = .002), and more frequently developed non-sustained (<8 beats, p = .007) and sustained ventricular tachycardia (≥8 beats; p < .001). However, after adjustment for confounders, there was no independent association between QTc duration and odds of ventricular tachyarrhythmia (OR = 0.921 [0.593-1.431], p = .715). Moreover, 98% of ventricular tachyarrhythmias resolved spontaneously. Patients with QTc prolongation had longer ICU (p < .001) and hospital length-of-stay (p = .002), and greater ICU (p = .030) and in-hospital mortality (p = .015). No patient experienced sustained Torsades de Pointes or died from ventricular arrhythmia. A QTc ≥500 ms likely represents a marker of illness severity modulated by several risk factors, and carries no independent association with clinically-significant ventricular tachyarrhythmias. Thus, cessation of QT-prolonging medications to prevent arrhythmias may lack clinical benefit.en
dc.language.isoeng
dc.subjectCritically illen
dc.subjectICUen
dc.subjectQTen
dc.subjectQTcen
dc.subjectTorsades de Pointesen
dc.subjectVentricular arrhythmiaen
dc.titleThe incidence, predictors and outcomes of QTc prolongation in critically ill patients.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Critical Careen
dc.identifier.affiliationMelbourne Medical School (Austin Clinical School), The University of Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Intensive Care, Austin Hospital, Heidelberg, Melbourne, Australiaen
dc.identifier.affiliationCentre for Integrated Critical Care, The University of Melbourne, Victoria, Australiaen
dc.identifier.affiliationFaculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australiaen
dc.identifier.affiliationIntensive Careen
dc.identifier.doi10.1016/j.jcrc.2019.09.014en
dc.type.contentTexten
dc.identifier.pubmedid31630074
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptIntensive Care-
crisitem.author.deptIntensive Care-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

46
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.