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DC Field | Value | Language |
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dc.contributor.author | Khor, Yet H | - |
dc.contributor.author | Ng, Yvonne | - |
dc.contributor.author | Barnes, Hayley | - |
dc.contributor.author | Goh, Nicole S L | - |
dc.contributor.author | McDonald, Christine F | - |
dc.contributor.author | Holland, Anne E | - |
dc.date | 2020-08-04 | - |
dc.date.accessioned | 2020-09-28T20:42:01Z | - |
dc.date.available | 2020-09-28T20:42:01Z | - |
dc.date.issued | 2020-09-30 | - |
dc.identifier.citation | European Respiratory Review 2020; 29(157): 190158 | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/24516 | - |
dc.description.abstract | In addition to facilitating healthcare delivery planning, reliable information about prognosis is essential for treatment decisions in patients with idiopathic pulmonary fibrosis (IPF). This review aimed to evaluate the prognosis of patients with IPF without anti-fibrotic therapy. We included all cohort studies and the placebo arms of randomised controlled trials (RCTs) in IPF and follow-up of ≥12 months. Two reviewers independently evaluated studies for inclusion, assessed risk of bias and extracted data. A total of 154 cohort studies and 16 RCTs were included. The pooled proportions of mortality were 0.12 (95% CI 0.09-0.14) at 1-2 years, 0.38 (95% CI 0.34-0.42) between 2-5 years, and 0.69 (95% CI 0.59-0.78) at ≥5 years. The pooled mean overall survival was 4 years (95% CI 3.7-4.6) for studies with a follow-up duration of 10 years. At <2 years, forced vital capacity and diffusing capacity of the lung for carbon monoxide declined by a mean of 6.76% predicted (95% CI -8.92 -4.61) and 3% predicted (95% CI -5.14 -1.52), respectively. Although heterogeneity was high, subgroup analyses revealed lower pooled proportions of mortality at 1 year in the RCT participants (0.07 (95% CI 0.05-0.09)) versus cohort study participants (0.14 (95% CI 0.12-0.17)). This review provides comprehensive information on the prognosis of IPF, which can inform treatment discussions with patients and comparisons for future studies with new therapies. | en |
dc.language.iso | eng | |
dc.title | Prognosis of idiopathic pulmonary fibrosis without anti-fibrotic therapy: a systematic review. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | European Respiratory Review | en |
dc.identifier.affiliation | Respiratory and Sleep Medicine | en |
dc.identifier.affiliation | Institute for Breathing and Sleep | en |
dc.identifier.affiliation | Dept of Respiratory Medicine, Alfred Health, Melbourne, Australia | en |
dc.identifier.affiliation | School of Medicine, University of Melbourne, Melbourne, Australia | en |
dc.identifier.affiliation | Dept of Respiratory Medicine, Alfred Health, Melbourne, Australia | en |
dc.identifier.affiliation | Dept of Physiotherapy, Alfred Health and Monash University, Melbourne, Australia | en |
dc.identifier.affiliation | Dept of Respiratory Medicine, Alfred Health, Melbourne, Australia | en |
dc.identifier.affiliation | Monash Lung and Sleep, Monash Health, Clayton, Australia | en |
dc.identifier.doi | 10.1183/16000617.0158-2019 | en |
dc.type.content | Text | en |
dc.identifier.orcid | 0000-0002-5434-9342 | en |
dc.identifier.orcid | 0000-0002-7615-4191 | en |
dc.identifier.orcid | 0000-0003-2061-845X | en |
dc.identifier.pubmedid | 32759374 | |
local.name.researcher | Goh, Nicole S L | |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | Journal Article | - |
crisitem.author.dept | Respiratory and Sleep Medicine | - |
crisitem.author.dept | Institute for Breathing and Sleep | - |
crisitem.author.dept | Medicine (University of Melbourne) | - |
crisitem.author.dept | Respiratory and Sleep Medicine | - |
crisitem.author.dept | Institute for Breathing and Sleep | - |
crisitem.author.dept | Institute for Breathing and Sleep | - |
crisitem.author.dept | Respiratory and Sleep Medicine | - |
crisitem.author.dept | Institute for Breathing and Sleep | - |
crisitem.author.dept | Physiotherapy | - |
Appears in Collections: | Journal articles |
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