Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/23876
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dc.contributor.authorRethnam, Venesha-
dc.contributor.authorLanghorne, Peter-
dc.contributor.authorChurilov, Leonid-
dc.contributor.authorHayward, Kathryn S-
dc.contributor.authorHerisson, Fanny-
dc.contributor.authorPoletto, Simone R-
dc.contributor.authorTong, Yanna-
dc.contributor.authorBernhardt, Julie-
dc.date2020-07-16-
dc.date.accessioned2020-07-27T05:09:35Z-
dc.date.available2020-07-27T05:09:35Z-
dc.date.issued2022-
dc.identifier.citationDisability and Rehabilitation 2022; 44(8): 1156-1163en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/23876-
dc.description.abstractTo investigate the safety and efficacy of early mobilisation (EM) compared to usual care by meta-analysing individual participant data (IPD). IPD were sought from randomised controlled trials comparing out-of-bed mobilisation starting within 48 h from stroke onset to usual care for acute stroke patients. Six trials were sourced from a recent Cochrane review. Favourable outcome (modified Rankin Scale 0-2) and death at 3 months post-stroke were compared between both groups using mixed-effect logistic regression modelling. Adjusted odds ratios (aORs) with respective 95% confidence intervals (95%CI) were reported. Out of 2630 participants, 1437 (54.6%) were assigned to EM and 1193 (45.4%) to usual care. Intervention protocols varied considerably between trials. The median (interquartile range) delay to starting mobilisation post-stroke onset was 20 h (14.5-23.8) for EM and 23 h (16.7-34.3) for usual care group. Fewer EM participants had a favourable outcome at 3 months post-stroke compared to the usual care group (678 [48%] vs. 611 [52%]; aOR = 0.75, 95%CI: 0.62-0.92, p = 0.005). No difference in death at 3 months post-stroke between EM and usual care was observed (102 [7%] vs. 84 [7%]; aOR = 1.46, 95%CI: 0.92-2.31, p = 0.108). The commencement of mobilisation should only be considered after 24 h post-stroke. Further research is required to identify safe, optimal dose, and timing of EM post-stroke. IMPLICATIONS FOR REHABILITATION Patients who commenced mobilisation early after stroke had worse outcome than usual care. Insufficient detail about mobilisation interventions or usual care in many studies limits any further interpretation. The commencement of mobilisation should only be considered after 24-h post-stroke.en
dc.language.isoeng-
dc.subjectStrokeen
dc.subjectacuteen
dc.subjectmobilityen
dc.subjectrecoveryen
dc.subjectrehabilitationen
dc.titleEarly mobilisation post-stroke: a systematic review and meta-analysis of individual participant data.en
dc.typeJournal Articleen
dc.identifier.journaltitleDisability and Rehabilitationen
dc.identifier.affiliationDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USAen
dc.identifier.affiliationInstitute of Cardiovascular and Medical Sciences, Royal Infirmary, Glasgow, UKen
dc.identifier.affiliationMelbourne Medical School, University of Melbourne, Parkville, Australiaen
dc.identifier.affiliationMelbourne School of Health Sciences, University of Melbourne, Parkville, Australiaen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Healthen
dc.identifier.affiliationNHMRC Centre for Research Excellence in Stroke Rehabilitation and Brain Recovery, Melbourne, Australiaen
dc.identifier.affiliationClinical School of Physiotherapy, Lutheran University of Brazil, Canoas, Brazilen
dc.identifier.affiliationChina-America Institute of Neuroscience, Beijing Luhe Hospital, Beijing, Chinaen
dc.identifier.doi10.1080/09638288.2020.1789229en
dc.type.contentTexten
dc.identifier.orcid0000-0002-0493-8536en
dc.identifier.orcid0000-0001-8185-2659en
dc.identifier.orcid0000-0002-9807-6606en
dc.identifier.orcid0000-0001-5240-3264en
dc.identifier.orcid0000-0001-9391-7421en
dc.identifier.orcid0000-0002-5619-7856en
dc.identifier.orcid0000-0002-1411-1583en
dc.identifier.orcid0000-0002-2787-8484en
dc.identifier.pubmedid32673130-
dc.type.austinJournal Article-
local.name.researcherChurilov, Leonid
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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