Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/23860
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dc.contributor.authorNightscales, Russell-
dc.contributor.authorMcCartney, Lara-
dc.contributor.authorAuvrez, Clarissa-
dc.contributor.authorTao, Gerard-
dc.contributor.authorBarnard, Sarah-
dc.contributor.authorMalpas, Charles B-
dc.contributor.authorPerucca, Piero-
dc.contributor.authorMcIntosh, Anne-
dc.contributor.authorChen, Zhibin-
dc.contributor.authorSivathamboo, Shobi-
dc.contributor.authorIgnatiadis, Sophia-
dc.contributor.authorJones, Simon-
dc.contributor.authorAdams, Sophia-
dc.contributor.authorCook, Mark J-
dc.contributor.authorKwan, Patrick-
dc.contributor.authorVelakoulis, Dennis-
dc.contributor.authorD'Souza, Wendyl-
dc.contributor.authorBerkovic, Samuel F-
dc.contributor.authorO'Brien, Terence J-
dc.date2020-07-20-
dc.date.accessioned2020-07-27T05:09:33Z-
dc.date.available2020-07-27T05:09:33Z-
dc.date.issued2020-08-11-
dc.identifier.citationNeurology 2020; 95(6): e643-e652en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/23860-
dc.description.abstractTo investigate the hypothesis that patients diagnosed with psychogenic nonepileptic seizures (PNES) on video-EEG monitoring (VEM) have increased mortality by comparison to the general population. This retrospective cohort study included patients evaluated in VEM units of 3 tertiary hospitals in Melbourne, Australia, between January 1, 1995, and December 31, 2015. Diagnosis was based on consensus opinion of experienced epileptologists and neuropsychiatrists at each hospital. Mortality was determined in patients diagnosed with PNES, epilepsy, or both conditions by linkage to the Australian National Death Index. Lifetime history of psychiatric disorders in PNES was determined from formal neuropsychiatric reports. A total of 5,508 patients underwent VEM. A total of 674 (12.2%) were diagnosed with PNES, 3064 (55.6%) with epilepsy, 175 (3.2%) with both conditions, and 1,595 (29.0%) received other diagnoses or had no diagnosis made. The standardized mortality ratio (SMR) of patients diagnosed with PNES was 2.5 (95% confidence interval [CI] 2.0-3.3). Those younger than 30 had an 8-fold higher risk of death (95% CI 3.4-19.8). Direct comparison revealed no significant difference in mortality rate between diagnostic groups. Among deaths in patients diagnosed with PNES (n = 55), external causes contributed 18%, with 20% of deaths in those younger than 50 years attributed to suicide, and "epilepsy" was recorded as the cause of death in 24%. Patients diagnosed with PNES have a SMR 2.5 times above the general population, dying at a rate comparable to those with drug-resistant epilepsy. This emphasizes the importance of prompt diagnosis, identification of risk factors, and implementation of appropriate strategies to prevent potential avoidable deaths.en
dc.language.isoeng-
dc.titleMortality in patients with psychogenic nonepileptic seizures.en
dc.typeJournal Articleen_US
dc.identifier.journaltitleNeurologyen
dc.identifier.affiliationDepartment of Neuroscience, Central Clinical School, and Clinical Epidemiology, School of Public Health and Preventive Medicine, Monash University, Melbourneen
dc.identifier.affiliationDepartments of Medicine and Neurology and Neuropsychiatry Unit, The Royal Melbourne Hospital, Parkville, Australiaen
dc.identifier.affiliationThe Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, Australiaen
dc.identifier.affiliationDepartment of Neurology, The Alfred Hospital, Melbourne, Australiaen
dc.identifier.affiliationDepartment of Medicine, St. Vincent's Hospital, The University of Melbourne, Fitzroy, Australiaen
dc.identifier.affiliationDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationEpilepsy Research Centre, Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1212/WNL.0000000000009855en
dc.type.contentTexten_US
dc.identifier.orcid0000-0001-9108-207Xen
dc.identifier.orcid0000-0003-0534-3718en
dc.identifier.orcid0000-0002-7855-7066en
dc.identifier.orcid0000-0002-5020-260Xen
dc.identifier.orcid0000-0002-1888-6917en
dc.identifier.orcid0000-0003-4638-9579en
dc.identifier.orcid0000-0002-8875-4135en
dc.identifier.orcid0000-0001-7310-276Xen
dc.identifier.orcid0000-0002-8842-8479en
dc.identifier.orcid0000-0002-1750-5131en
dc.identifier.orcid0000-0003-4580-841Xen
dc.identifier.orcid0000-0002-7198-8621en
dc.identifier.pubmedid32690794-
dc.type.austinJournal Article-
local.name.researcherBerkovic, Samuel F
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptNeurology-
crisitem.author.deptComprehensive Epilepsy Program-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
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