Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/23477
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dc.contributor.authorTran, Bang Manh-
dc.contributor.authorFlanagan, Dustin James-
dc.contributor.authorEbert, Gregor-
dc.contributor.authorWarner, Nadia-
dc.contributor.authorTran, Hoanh-
dc.contributor.authorFifis, Theodora-
dc.contributor.authorKastrappis, Georgios-
dc.contributor.authorChristophi, Christopher-
dc.contributor.authorPellegrini, Marc-
dc.contributor.authorTorresi, Joseph-
dc.contributor.authorPhesse, Toby James-
dc.contributor.authorVincan, Elizabeth-
dc.date2020-05-31-
dc.date.accessioned2020-06-10T00:47:13Z-
dc.date.available2020-06-10T00:47:13Z-
dc.date.issued2020-05-31-
dc.identifier.citationCancers 2020; 12(6): E1435-
dc.identifier.issn2072-6694-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/23477-
dc.description.abstractAn emerging theme for Wnt-addicted cancers is that the pathway is regulated at multiple steps via various mechanisms. Infection with hepatitis B virus (HBV) is a major risk factor for liver cancer, as is deregulated Wnt signaling, however, the interaction between these two causes is poorly understood. To investigate this interaction, we screened the effect of the various HBV proteins for their effect on Wnt/β-catenin signaling and identified the pre-core protein p22 as a novel and potent activator of TCF/β-catenin transcription. The effect of p22 on TCF/β-catenin transcription was dose dependent and inhibited by dominant-negative TCF4. HBV p22 activated synthetic and native Wnt target gene promoter reporters, and TCF/β-catenin target gene expression in vivo. Importantly, HBV p22 activated Wnt signaling on its own and in addition to Wnt or β-catenin induced Wnt signaling. Furthermore, HBV p22 elevated TCF/β-catenin transcription above constitutive activation in colon cancer cells due to mutations in downstream genes of the Wnt pathway, namely APC and CTNNB1. Collectively, our data identifies a previously unappreciated role for the HBV pre-core protein p22 in elevating Wnt signaling. Understanding the molecular mechanisms of p22 activity will provide insight into how Wnt signaling is fine-tuned in cancer.-
dc.language.isoeng-
dc.subjectHBV-
dc.subjectTCF/LEF-
dc.subjectWnt signaling-
dc.subjectcancer-
dc.subjecthepatitis B virus-
dc.subjectliver cancer-
dc.subjectβ-catenin-
dc.titleThe Hepatitis B Virus Pre-Core Protein p22 Activates Wnt Signaling.-
dc.typeJournal Article-
dc.identifier.journaltitleCancers-
dc.identifier.affiliationCancer Research UK Beatson Institute, Glasgow G61 1BD, UKen
dc.identifier.affiliationSchool of Pharmacy and Biomedical Sciences, Curtin University, Perth, WA 6102, Australiaen
dc.identifier.affiliationEuropean Cancer Stem Cell Research Institute, Cardiff University, Cardiff CF24 4HQ, UKen
dc.identifier.affiliationDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne 3000, Australiaen
dc.identifier.affiliationThe Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australiaen
dc.identifier.affiliationDepartment of Medical Biology, The University of Melbourne, Melbourne 3010, Australiaen
dc.identifier.affiliationDepartment of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationThe Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne 3000, Australiaen
dc.identifier.affiliationVictorian Infectious Diseases Reference Laboratory, The Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Australiaen
dc.identifier.doi10.3390/cancers12061435-
dc.identifier.orcid0000-0002-4252-086X-
dc.identifier.orcid0000-0002-8212-0887-
dc.identifier.orcid0000-0001-9568-4916-
dc.identifier.orcid0000-0002-8607-4849-
dc.identifier.pubmedid32486480-
dc.type.austinJournal Article-
local.name.researcherChristophi, Christopher
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptSurgery-
crisitem.author.deptHepatopancreatobiliary Surgery-
crisitem.author.deptInfectious Diseases-
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