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Title: How can Australia integrate routine genetic sequencing in oncology: a qualitative study through an implementation science lens.
Austin Authors: O'Shea, Rosie;Rankin, Nicole M;Kentwell, Maira;Gleeson, Margaret;Salmon, Lucinda ;Tucker, Katherine M;Lewis, Sarah;Taylor, Natalie
Affiliation: Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia
Discipline of Genetic Counselling, Graduate School of Health, University of Technology Sydney, Sydney, NSW, Australia
Parkville Familial Cancer Centre, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Parkville, VIC, Australia
Department of Oncology, Royal Women's Hospital Parkville, Parkville, VIC, Australia
Hunter Family Cancer Service, Newcastle, NSW, Australia
Department of Clinical Genetics, Austin Health, Heidelberg, Victoria, Australia
Hereditary Cancer Clinic, Prince of Wales Hospital, University of New South Wales, UNSW, Sydney, NSW, Australia
Cancer Research Division, Cancer Council NSW, Sydney, NSW, Australia
Issue Date: 28-May-2020
Date: 2020-05-28
Publication information: Genetics in medicine : official journal of the American College of Medical Genetics 2020; online first: 28 May
Abstract: This study sought to determine genetics and oncology specialists' views of integrating BRCA1 and BRCA2 testing in epithelial ovarian and breast cancer into routine practice. Qualitative interviews were designed using the Consolidated Framework for Implementation Research. Questions included experiences or views of the BRCA testing processes, implementation needs of oncology health professionals, perceived challenges, and future ideas for interventions to integrate genetic testing into oncology. Twenty-two participants were interviewed from twelve health organizations and four themes were identified: (1) embracing the shift to mainstream genetic testing, with the majority of participants viewing BRCA testing as clinically useful and routine use important for maintaining a patient centered process; (2) the need for communication networks and role delineation to integrate routine genetic testing; (3) factors that influence sustaining routine genetic testing, including ongoing training, resources and funding, real-world adaptation, system complexity, and champions; and (4) variation in system interventions for integrating routine genetic testing align to organizational context. Findings illustrate the need for integrating genetic testing into routine oncology, and that adaptation of interventions and processes is essential to sustain a feasible model. An understanding of individual and organizational implementation factors will help to prepare for future integration of routine genetic testing in other cancers.
DOI: 10.1038/s41436-020-0838-x
ORCID: 0000-0002-9186-1644
Journal: Genetics in medicine : official journal of the American College of Medical Genetics
PubMed URL: 32461668
Type: Journal Article
Subjects: interventions and implementation
routine genetic testing
Appears in Collections:Journal articles

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