Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/23269
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dc.contributor.authorGleeson, Mary-
dc.contributor.authorCounsell, Nicholas-
dc.contributor.authorCunningham, David-
dc.contributor.authorLawrie, Anthony-
dc.contributor.authorClifton-Hadley, Laura-
dc.contributor.authorHawkes, Eliza A-
dc.contributor.authorMcMillan, Andrew-
dc.contributor.authorArdeshna, Kirit M-
dc.contributor.authorBurton, Cathy-
dc.contributor.authorChadwick, Nick-
dc.contributor.authorGambell, Joanna-
dc.contributor.authorSmith, Paul-
dc.contributor.authorMouncey, Paul-
dc.contributor.authorPocock, Christopher-
dc.contributor.authorRadford, John-
dc.contributor.authorDavies, John-
dc.contributor.authorTurner, Deborah-
dc.contributor.authorKruger, Anton-
dc.contributor.authorJohnson, Peter-
dc.contributor.authorLinch, David-
dc.date2020-05-20-
dc.date.accessioned2020-05-25T05:23:33Z-
dc.date.available2020-05-25T05:23:33Z-
dc.date.issued2021-03-
dc.identifier.citationBritish Journal of Haematology 2021; 192(6): 1015-1019-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/23269-
dc.description.abstractWe compared the International Prognostic Index (IPI), Revised (R)-IPI and age-adjusted (aa)-IPI as prognostic indices for patients with diffuse large B-cell lymphoma (DLBCL) in the UK National Cancer Research Institute (NCRI) R-CHOP 14 versus 21 trial (N = 1080). The R-IPI and aa-IPI showed no marked improvement compared to the IPI for overall and progression-free survival, in terms of model fit or discrimination. Similar results were observed in exploratory analyses incorporating the Grupo Español de Linfomas/Transplante de Médula Ósea (GELTAMO)-IPI, where baseline β2-microglobulin data were available (N = 655). Although our findings support current use of the IPI, a novel prognostic tool to better delineate a high-risk DLBCL group in the rituximab era is needed.-
dc.language.isoeng-
dc.subjectclinical trials-
dc.subjectdiffuse large B-cell lymphoma-
dc.subjectinternational prognostic index-
dc.subjectrituximab-
dc.titlePrognostic indices in diffuse large B-cell lymphoma in the rituximab era: an analysis of the UK National Cancer Research Institute R-CHOP 14 versus 21 phase 3 trial.-
dc.typeJournal Article-
dc.identifier.journaltitleBritish Journal of Haematology-
dc.identifier.affiliationGuy's and St Thomas' NHS Foundation Trust, London, UKen
dc.identifier.affiliationDepartment of Clinical Haematology, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationMount Vernon Cancer Centre, Northwood, UKen
dc.identifier.affiliationDepartment of Medical Oncology, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationWestern General Hospital, Edinburgh, UKen
dc.identifier.affiliationCancer Research UK Centre, Southampton, UKen
dc.identifier.affiliationThe University of Manchester and the Christie NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UKen
dc.identifier.affiliationEast Kent Hospitals, Canterbury, UKen
dc.identifier.affiliationHMDS, Leeds Teaching Hospitals NHS Trust, Leeds, UKen
dc.identifier.affiliationNottingham City Hospital, Nottingham, UKen
dc.identifier.affiliationThe Royal Marsden Hospital, London and Surrey, London, UKen
dc.identifier.affiliationCancer Research UK and UCL Cancer Trials Centre, UCL Cancer Institute, London, UKen
dc.identifier.affiliationUniversity College London, London, UKen
dc.identifier.affiliationRoyal Cornwall Hospital, Truro, UKen
dc.identifier.affiliationTorbay Hospital, Torquay, UKen
dc.identifier.affiliationThe Royal Marsden Hospital, London and Surrey, London, UKen
dc.identifier.affiliationUniversity College London, London, UKen
dc.identifier.affiliationEastern Health, Melbourne, Australiaen
dc.identifier.doi10.1111/bjh.16691-
dc.identifier.orcid0000-0001-6915-9878-
dc.identifier.orcid0000-0002-9988-5528en
dc.identifier.orcid0000-0002-0376-2559en
dc.identifier.pubmedid32436212-
dc.type.austinJournal Article-
local.name.researcherHawkes, Eliza A
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptClinical Haematology-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
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