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dc.contributor.authorCarvalho, Lilian B-
dc.contributor.authorKramer, Sharon F-
dc.contributor.authorBorschmann, Karen-
dc.contributor.authorChambers, Brian R-
dc.contributor.authorThijs, Vincent N-
dc.contributor.authorBernhardt, Julie-
dc.identifier.citationJournal of Cerebral Blood Flow and Metabolism 2020; online first: 13 Mayen_US
dc.description.abstractThe effects of upright postures on the cerebral circulation early post-ischaemic stroke are not fully understood. We conducted a systematic review and meta-analysis to investigate the effects of head positioning on cerebral haemodynamics assessed by imaging methods post-ischaemic stroke. Of the 21 studies included (n = 529), 15 used transcranial Doppler. Others used near-infrared, diffuse correlation spectroscopy and nuclear medicine modalities. Most tested head positions between 0° and 45°. Seventeen studies reported changes in CBF parameters (increase at lying-flat or decrease at more upright) in the ischaemic hemisphere with position change. However, great variability was found and risk of bias was high in many studies. Pooled data of two studies ≤24 h (n = 28) showed a mean increase in cerebral blood flow (CBF) velocity of 8.5 cm/s in the ischaemic middle cerebral artery (95%CI,-2.2-19.3) from 30° to 0°. The increase found ≤48 h (n = 50) was of 2.3 cm/s (95%CI,-4.6-9.2), while ≤7 days (n = 38) was of 8.4 cm/s (95%CI, 1.8-15). Few very early studies (≤2 days) tested head positions greater than 30° and were unable to provide information about the response of acute stroke patients to upright postures (sitting, standing). These postures are part of current clinical practice and knowledge on their effects on cerebral haemodynamics is required.en_US
dc.subjectIschaemic Strokeen_US
dc.subjectcerebral blood flowen_US
dc.subjectcerebral haemodynamicsen_US
dc.subjecthead positionen_US
dc.subjectupright positionen_US
dc.titleCerebral haemodynamics with head position changes post-ischaemic stroke: A systematic review and meta-analysis.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of Cerebral Blood Flow and Metabolismen_US
dc.identifier.affiliationSt Vincent's Hospital, Melbourne, Australiaen_US
dc.identifier.affiliationDepartment of Neurology, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Healthen_US
dc.identifier.affiliationNHMRC Centre for Research Excellence in Stroke Rehabilitation and Brain Recovery, Heidelberg, Australiaen_US
dc.type.austinJournal Article-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications- Florey Institute of Neuroscience and Mental Health- Florey Institute of Neuroscience and Mental Health- Florey Institute of Neuroscience and Mental Health-
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