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dc.contributor.authorYanase, Fumitaka-
dc.contributor.authorFujii, Tomoko-
dc.contributor.authorNaorungroj, Thummaporn-
dc.contributor.authorBelletti, Alessandro-
dc.contributor.authorLuethi, Nora-
dc.contributor.authorCarr, Anitra C-
dc.contributor.authorYoung, Paul J-
dc.contributor.authorBellomo, Rinaldo-
dc.identifier.citationCritical Care Medicine 2020; online first: 13 May-
dc.description.abstractThe potential harm associated with the use of IV vitamin C has not been systematically assessed. We aimed to review the available evidence on harm related to such treatment. We searched MEDLINE, EMBASE, Cochrane Library, National Institute of Health Clinical Trials Register, and World Health Organization International Clinical Trials Registry Platform. We included studies in adult population that reported harm related to IV high-dose vitamin C which we defined as greater than or equal to 6 g/d, greater than or equal to 75 mg/kg/d, or greater than or equal to 3 g/m/d. Two independent investigators screened records and extracted data. We identified 8,149 reports, of which 650 full text were assessed for eligibility, leaving 74 eligible studies. In these studies, 2,801 participants received high-dose vitamin C at a median (interquartile range) dose of 22.5 g/d (8.25-63.75 g/d), 455 mg/kg/d (260-925 mg/kg/d), or 70 g/m/d (50-90 g/m/d); and 932 or more adverse events were reported. Among nine double-blind randomized controlled trials (2,310 patients), adverse events were reported in three studies with an event rate per patient for high-dose vitamin C identical to placebo group in one study (0.1 [1/10] vs 0.1 [1/10]), numerically lower in one study (0.80 [672/839] vs 0.82 [709/869]), and numerically higher in one study (0.33 [24/73] vs 0.23 [17/74]). Six double-blind randomized controlled trials reported no adverse event in either group. Five cases of oxalate nephropathy, five cases of hypernatremia, three cases of hemolysis in glucose-6-phosphate dehydrogenase deficiency patients, two cases of glucometer error, and one case of kidney stones were also reported overall. There is no consistent evidence that IV high-dose vitamin C therapy is more harmful than placebo in double-blind randomized controlled trials. However, reports of oxalate nephropathy, hypernatremia, glucometer error, and hemolysis in glucose-6-phosphate dehydrogenase deficiency patients warrant specific monitoring.-
dc.titleHarm of IV High-Dose Vitamin C Therapy in Adult Patients: A Scoping Review.-
dc.typeJournal Article-
dc.identifier.journaltitleCritical Care Medicine-
dc.identifier.affiliationCentre for Integrated Critical Care, Department of Medicine & Radiology, University of Melbourne, Melbourne, VIC, Australiaen
dc.identifier.affiliationDepartment of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine, Kyoto, Japanen
dc.identifier.affiliationDepartment of Intensive Care, Siriraj Hospital, Mahidol University, Bangkok, Thailanden
dc.identifier.affiliationDepartment of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italyen
dc.identifier.affiliationInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerlanden
dc.identifier.affiliationDepartment of Intensive Care, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australiaen
dc.identifier.affiliationNutrition in Medicine Research Group, Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand-
dc.identifier.affiliationIntensive Care Unit, Wellington Hospital, Wellington, New Zealand Medical Research Institute of New Zealand, Wellington, New Zealand-
dc.type.austinJournal Article-
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