Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/23091
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dc.contributor.authorAl-Khan, A A-
dc.contributor.authorNimmo, J S-
dc.contributor.authorDay, M J-
dc.contributor.authorTayebi, M-
dc.contributor.authorRyan, S D-
dc.contributor.authorKuntz, C A-
dc.contributor.authorSimcock, J O-
dc.contributor.authorTarzi, R-
dc.contributor.authorSaad, E S-
dc.contributor.authorRichardson, S J-
dc.contributor.authorDanks, Janine A-
dc.date2020-04-
dc.date.accessioned2020-05-05T23:59:23Z-
dc.date.available2020-05-05T23:59:23Z-
dc.date.issued2020-04-
dc.identifier.citationJournal of comparative pathology 2020; 176: 133-144-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/23091-
dc.description.abstractOsteosarcoma (OS) is an aggressive malignant bone neoplasm that occurs mostly in the appendicular skeleton of dogs and people. OS is classified based on the presence of malignant stroma and the formation of extracellular matrix into osteoblastic, chondroblastic and fibroblastic forms. This study investigated the correlation between the three histological subtypes of canine OS and clinical outcome. Additionally, we examined whether there was any difference in the immunolabelling of desmin, S100 and neuron-specific enolase (NSE) between the three histological subtypes. Formalin-fixed and paraffin wax-embedded tissues from 87 dogs with primary OS were available for this study. The survival times were correlated with appendicular OS subtypes in dogs that were treated surgically, received adjuvant chemotherapy and had no pulmonary metastasis at the time of diagnosis. Dogs with an appendicular fibroblastic OS had significantly prolonged mean average survival times (546 ± 105 days) in comparison with dogs having appendicular osteoblastic (257 ± 48 days) or appendicular chondroblastic (170 ± 28 days) OS (P = 0.003, Log Rank). The results also revealed that the appendicular chondroblastic subtype is a significant indicator for poor prognosis in dogs compared with the fibroblastic or osteoblastic subtypes (P = 0.006, Cox regression). Moreover, the findings indicated that there was no significant correlation between the localization of desmin, NSE or S100 and histological subtypes. Importantly, dogs with appendicular fibroblastic OS were found to have a better prognosis when compared with dogs with other subtypes. This may suggest that histological subtypes of appendicular OS have diverse behaviour and could be used to categorize patients for risk-based assessment.-
dc.language.isoeng-
dc.subjectdog-
dc.subjecthistological subtype-
dc.subjectosteosarcoma-
dc.subjectsurvival time-
dc.titleFibroblastic Subtype has a Favourable Prognosis in Appendicular Osteosarcoma of Dogs.-
dc.typeJournal Article-
dc.identifier.journaltitleJournal of comparative pathology-
dc.identifier.affiliationSchool of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia-
dc.identifier.affiliationSchool of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationSchool of Veterinary and Life Sciences, Murdoch University, Murdoch, Western Australia, Australiaen
dc.identifier.affiliationAustralian Specialised Animal Pathology Laboratory, Mulgrave, Victoria, Australia-
dc.identifier.affiliationSchool of Medicine, Western Sydney University, Campbelltown, New South Wales, Australiaen
dc.identifier.affiliationTranslational Research and Animal Clinical Trial Study Group (TRACTS), Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Werribee, Victoria, Australia-
dc.identifier.affiliationSouthpaws Veterinary Hospital, Moorabbin, Victoria, Australia-
dc.identifier.affiliationSchool of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia-
dc.identifier.doi10.1016/j.jcpa.2020.02.011-
dc.identifier.orcid0000-0002-2789-3449-
dc.identifier.pubmedid32359626-
dc.type.austinJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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