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https://ahro.austin.org.au/austinjspui/handle/1/23074
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DC Field | Value | Language |
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dc.contributor.author | Beyer, Leonie | - |
dc.contributor.author | Nitschmann, Alexander | - |
dc.contributor.author | Barthel, Henryk | - |
dc.contributor.author | van Eimeren, Thilo | - |
dc.contributor.author | Unterrainer, Marcus | - |
dc.contributor.author | Sauerbeck, Julia | - |
dc.contributor.author | Marek, Ken | - |
dc.contributor.author | Song, Mengmeng | - |
dc.contributor.author | Palleis, Carla | - |
dc.contributor.author | Respondek, Gesine | - |
dc.contributor.author | Hammes, Jochen | - |
dc.contributor.author | Barbe, Michael T | - |
dc.contributor.author | Onur, Özgür | - |
dc.contributor.author | Jessen, Frank | - |
dc.contributor.author | Saur, Dorothee | - |
dc.contributor.author | Schroeter, Matthias L | - |
dc.contributor.author | Rumpf, Jost-Julian | - |
dc.contributor.author | Rullmann, Michael | - |
dc.contributor.author | Schildan, Andreas | - |
dc.contributor.author | Patt, Marianne | - |
dc.contributor.author | Neumaier, Bernd | - |
dc.contributor.author | Barret, Olivier | - |
dc.contributor.author | Madonia, Jennifer | - |
dc.contributor.author | Russell, David S | - |
dc.contributor.author | Stephens, Andrew W | - |
dc.contributor.author | Roeber, Sigrun | - |
dc.contributor.author | Herms, Jochen | - |
dc.contributor.author | Bötzel, Kai | - |
dc.contributor.author | Levin, Johannes | - |
dc.contributor.author | Classen, Joseph | - |
dc.contributor.author | Höglinger, Günter U | - |
dc.contributor.author | Bartenstein, Peter | - |
dc.contributor.author | Villemagne, Victor L | - |
dc.contributor.author | Drzezga, Alexander | - |
dc.contributor.author | Seibyl, John | - |
dc.contributor.author | Sabri, Osama | - |
dc.contributor.author | Brendel, Matthias | - |
dc.date | 2020-04-21 | - |
dc.date.accessioned | 2020-04-28T23:20:03Z | - |
dc.date.available | 2020-04-28T23:20:03Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.citation | European Journal of Nuclear Medicine and Molecular Imaging 2020; 47(12): 2911-2922 | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/23074 | - |
dc.description.abstract | Second-generation tau radiotracers for use with positron emission tomography (PET) have been developed for visualization of tau deposits in vivo. For several β-amyloid and first-generation tau-PET radiotracers, it has been shown that early-phase images can be used as a surrogate of neuronal injury. Therefore, we investigated the performance of early acquisitions of the novel tau-PET radiotracer [18F]PI-2620 as a potential substitute for [18F]fluorodeoxyglucose ([18F]FDG). Twenty-six subjects were referred with suspected tauopathies or overlapping parkinsonian syndromes (Alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, multi-system atrophy, Parkinson's disease, multi-system atrophy, Parkinson's disease, frontotemporal dementia) and received a dynamic [18F]PI-2620 tau-PET (0-60 min p.i.) and static [18F]FDG-PET (30-50 min p.i.). Regional standardized uptake value ratios of early-phase images (single frame SUVr) and the blood flow estimate (R1) of [18F]PI-2620-PET were correlated with corresponding quantification of [18F]FDG-PET (global mean/cerebellar normalization). Reduced tracer uptake in cortical target regions was also interpreted visually using 3-dimensional stereotactic surface projections by three more and three less experienced readers. Spearman rank correlation coefficients were calculated between early-phase [18F]PI-2620 tau-PET and [18F]FDG-PET images for all cortical regions and frequencies of disagreement between images were compared for both more and less experienced readers. Highest agreement with [18F]FDG-PET quantification was reached for [18F]PI-2620-PET acquisition from 0.5 to 2.5 min p.i. for global mean (lowest R = 0.69) and cerebellar scaling (lowest R = 0.63). Correlation coefficients (summed 0.5-2.5 min SUVr & R1) displayed strong agreement in all cortical target regions for global mean (RSUVr 0.76, RR1 = 0.77) and cerebellar normalization (RSUVr 0.68, RR1 = 0.68). Visual interpretation revealed high regional correlations between early-phase tau-PET and [18F]FDG-PET. There were no relevant differences between more and less experienced readers. Early-phase imaging of [18F]PI-2620 can serve as a surrogate biomarker for neuronal injury. Dynamic imaging or a dual time-point protocol for tau-PET imaging could supersede additional [18F]FDG-PET imaging by indexing both the distribution of tau and the extent of neuronal injury. | en |
dc.language.iso | eng | - |
dc.subject | Neuronal injury | en |
dc.subject | PET | en |
dc.subject | Perfusion | en |
dc.subject | Tau | en |
dc.subject | [18F]PI-2620 | en |
dc.title | Early-phase [18F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | European journal of nuclear medicine and molecular imaging | en |
dc.identifier.affiliation | Department of Nuclear Medicine, University Hospital of Munich LMU Munich, Marchioninstraße 15, 81377, Munich, Germany | en |
dc.identifier.affiliation | Molecular Neuroimaging, inviCRO, New Haven, CT, USA | en |
dc.identifier.affiliation | Max- Planck-Institute of Human Cognitive and Brain Sciences, Leipzig, Germany | en |
dc.identifier.affiliation | German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany | en |
dc.identifier.affiliation | Department of Psychiatry, University Hospital Cologne, Cologne, Germany | en |
dc.identifier.affiliation | Center for Memory Disorders, University Hospital Cologne, Cologne, Germany | en |
dc.identifier.affiliation | Cognitive Neuroscience, Institute for Neuroscience and Medicine (INM-3), Research Centre Juelich, Juelich, Germany | en |
dc.identifier.affiliation | Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany | en |
dc.identifier.affiliation | Department of Neurology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany | en |
dc.identifier.affiliation | German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany | en |
dc.identifier.affiliation | Department of Nuclear Medicine, University Hospital of Munich LMU Munich, Marchioninstraße 15, 81377, Munich, Germany | en |
dc.identifier.affiliation | Munich Cluster for Systems Neurology (SyNergy), Munich, Germany | en |
dc.identifier.affiliation | Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australia | en |
dc.identifier.affiliation | The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia | en |
dc.identifier.affiliation | Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia | en |
dc.identifier.affiliation | Department of Neurology, Technische Universität München, Munich, Germany | en |
dc.identifier.affiliation | Department of Neurology, Hannover Medical School, Hannover, Germany | en |
dc.identifier.affiliation | Department of Nuclear Medicine, University Hospital of Munich LMU Munich, Marchioninstraße 15, 81377, Munich, Germany | en |
dc.identifier.affiliation | Department of Neurology, University Hospital of Munich, LMU Munich, Munich, Germany | en |
dc.identifier.affiliation | German Center for Neurodegenerative Diseases (DZNE), Munich, Germany | en |
dc.identifier.affiliation | Center for Neuropathology and Prion Research, University Hospital of Munich, LMU Munich, Munich, Germany | en |
dc.identifier.affiliation | InviCRO, LLC, Boston, MA, USA | en |
dc.identifier.affiliation | Institute of Neuroscience and Medicine, Nuclear Chemistry (INM-5), Forschungszentrum Juelich GmbH, Juelich, Germany | en |
dc.identifier.affiliation | Institute of Radiochemistry and Experimental Molecular Imaging, University Clinic Cologne, Cologne, Germany | en |
dc.identifier.affiliation | Clinic for Cognitive Neurology, University of Leipzig, Leipzig, Germany | en |
dc.identifier.affiliation | LIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany | en |
dc.identifier.affiliation | Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany | en |
dc.identifier.affiliation | Department of Nuclear Medicine, University Hospital of Munich LMU Munich, Marchioninstraße 15, 81377, Munich, Germany | en |
dc.identifier.affiliation | Department of Neurology, University Hospital of Munich, LMU Munich, Munich, Germany | en |
dc.identifier.affiliation | Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany | en |
dc.identifier.affiliation | Department of Neurology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany | en |
dc.identifier.affiliation | Department of Neurology, University of Leipzig Medical Center, Leipzig, Germany | en |
dc.identifier.affiliation | Center for Memory Disorders, University Hospital Cologne, Cologne, Germany | en |
dc.identifier.affiliation | Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany | en |
dc.identifier.affiliation | Life Molecular Imaging GmbH, Berlin, Germany | en |
dc.identifier.affiliation | Center for Neuropathology and Prion Research, University Hospital of Munich, LMU Munich, Munich, Germany | en |
dc.identifier.affiliation | Department of Neurology, University Hospital of Munich, LMU Munich, Munich, Germany | en |
dc.identifier.affiliation | Department of Neurology, University of Leipzig Medical Center, Leipzig, Germany | en |
dc.identifier.affiliation | Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany | en |
dc.identifier.doi | 10.1007/s00259-020-04788-w | en |
dc.type.content | Text | en |
dc.identifier.orcid | 0000-0002-5832-9875 | en |
dc.identifier.pubmedid | 32318783 | - |
dc.type.austin | Journal Article | - |
local.name.researcher | Villemagne, Victor L | |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | Journal Article | - |
crisitem.author.dept | Molecular Imaging and Therapy | - |
Appears in Collections: | Journal articles |
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