Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/23016
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DC Field | Value | Language |
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dc.contributor.author | Kramer, Gerbrand M | - |
dc.contributor.author | Yaqub, Maqsood | - |
dc.contributor.author | Vargas, Herbert A | - |
dc.contributor.author | Schuit, Robert C | - |
dc.contributor.author | Windhorst, Albert D | - |
dc.contributor.author | van den Eertwegh, Alfonsus J M | - |
dc.contributor.author | van der Veldt, Astrid A M | - |
dc.contributor.author | Bergman, Andries M | - |
dc.contributor.author | Burnazi, Eva M | - |
dc.contributor.author | Lewis, Jason S | - |
dc.contributor.author | Chua, Sua | - |
dc.contributor.author | Staton, Kevin D | - |
dc.contributor.author | Beattie, Brad J | - |
dc.contributor.author | Humm, John L | - |
dc.contributor.author | Davis, Ian D | - |
dc.contributor.author | Weickhardt, Andrew J | - |
dc.contributor.author | Scott, Andrew M | - |
dc.contributor.author | Morris, Michael J | - |
dc.contributor.author | Hoekstra, Otto S | - |
dc.contributor.author | Lammertsma, Adriaan A | - |
dc.date | 2019-03-08 | - |
dc.date.accessioned | 2020-04-17T00:40:17Z | - |
dc.date.available | 2020-04-17T00:40:17Z | - |
dc.date.issued | 2019-09 | - |
dc.identifier.citation | Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2019; 60(9): 1221-1227 | - |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/23016 | - |
dc.description.abstract | 18F-fluorodihydrotestosterone (18F-FDHT) PET/CT potentially provides a noninvasive method for assessment of androgen receptor expression in patients with metastatic castration-resistant prostate cancer (mCRPC). The objective of this study was to assess simplified methods for quantifying 18F-FDHT uptake in mCRPC patients and to assess effects of tumor perfusion on these 18F-FDHT uptake metrics. Methods: Seventeen mCRPC patients were included in this prospective observational multicenter study. Test and retest 30-min dynamic 18F-FDHT PET/CT scans with venous blood sampling were performed in 14 patients. In addition, arterial blood sampling and dynamic 15O-H2O scans were obtained in a subset of 6 patients. Several simplified methods were assessed: Patlak plots; SUV normalized to body weight (SUVBW), lean body mass (SUVLBM), whole blood (SUVWB), parent plasma activity concentration (SUVPP), area under the parent plasma curve (SUVAUC,PP), and area under the whole-blood input curve (SUVAUC,WB); and SUVBW corrected for sex hormone-binding globulin levels (SUVSHBG). Results were correlated with parameters derived from full pharmacokinetic 18F-FDHT and 15O-H2O. Finally, the repeatability of individual quantitative uptake metrics was assessed. Results: Eighty-seven 18F-FDHT-avid lesions were evaluated. 18F-FDHT uptake was best described by an irreversible 2-tissue-compartment model. Replacing the continuous metabolite-corrected arterial plasma input function with an image-derived input function in combination with venous sample data provided similar K i results (R2 = 0.98). Patlak K i and SUVAUC,PP showed an excellent correlation (R2 > 0.9). SUVBW showed a moderate correlation to K i (R2 = 0.70, presumably due to fast 18F-FDHT metabolism. When calculating SUVSHBG, correlation to K i improved (R2 = 0.88). The repeatability of full kinetic modeling parameters was inferior to that of simplified methods (repeatability coefficients > 36% vs. < 28%, respectively). 18F-FDHT uptake showed minimal blood flow dependency. Conclusion:18F-FDHT kinetics in mCRPC patients are best described by an irreversible 2-tissue-compartment model with blood volume parameter. SUVAUC,PP showed a near-perfect correlation with the irreversible 2-tissue-compartment model analysis and can be used for accurate quantification of 18F-FDHT uptake in whole-body PET/CT scans. In addition, SUVSHBG could potentially be used as an even simpler method to quantify 18F-FDHT uptake when less complex scanning protocols and accuracy are required. | - |
dc.language.iso | eng | - |
dc.subject | FDHT | - |
dc.subject | PET/CT | - |
dc.subject | Prostate cancer | - |
dc.subject | quantification | - |
dc.title | Assessment of Simplified Methods for Quantification of 18F-FDHT Uptake in Patients with Metastatic Castration-Resistant Prostate Cancer. | - |
dc.type | Journal Article | - |
dc.identifier.journaltitle | Journal of nuclear medicine : official publication, Society of Nuclear Medicine | - |
dc.identifier.affiliation | Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands | en |
dc.identifier.affiliation | Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. | - |
dc.identifier.affiliation | Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands | en |
dc.identifier.affiliation | Departments of Medical Oncology, Radiology, and Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands | en |
dc.identifier.affiliation | Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands | en |
dc.identifier.affiliation | Department of Medical Oncology, Austin Health, Heidelberg, Victoria, Australia | en |
dc.identifier.affiliation | Department of Radiology, Weill Cornell Medicine, New York, New York | en |
dc.identifier.affiliation | Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York | en |
dc.identifier.affiliation | Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands | en |
dc.identifier.affiliation | Department of Medicine, Weill Cornell Medicine, New York, New York | en |
dc.identifier.affiliation | Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; and | en |
dc.identifier.affiliation | Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York | en |
dc.identifier.affiliation | Monash University and Eastern Health, Eastern Health Clinical School, Box Hill, Australia | en |
dc.identifier.affiliation | Department of Molecular Imaging and Therapy, University of Melbourne, Heidelberg, Victoria, Australia | en |
dc.identifier.affiliation | Department of Nuclear Medicine, Royal Marsden NHS Foundation Trust, Sutton, United Kingdom.. | - |
dc.identifier.affiliation | Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia | - |
dc.identifier.doi | 10.2967/jnumed.118.220111 | - |
dc.identifier.orcid | 0000-0002-6656-295X | - |
dc.identifier.pubmedid | 30850488 | - |
dc.type.austin | Journal Article | - |
dc.type.austin | Multicenter Study | - |
dc.type.austin | Observational Study | - |
dc.type.austin | Research Support, N.I.H., Extramural | - |
dc.type.austin | Research Support, Non-U.S. Gov't | - |
local.name.researcher | Scott, Andrew M | |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | Journal Article | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Olivia Newton-John Cancer Research Institute | - |
crisitem.author.dept | Molecular Imaging and Therapy | - |
crisitem.author.dept | Olivia Newton-John Cancer Research Institute | - |
Appears in Collections: | Journal articles |
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