Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/22918
Full metadata record
DC FieldValueLanguage
dc.contributor.authorHan, Hui-Chen-
dc.contributor.authorParsons, Sarah A-
dc.contributor.authorTeh, Andrew W-
dc.contributor.authorSanders, Prashanthan-
dc.contributor.authorNeil, Christopher-
dc.contributor.authorLeong, Trishe-
dc.contributor.authorKoshy, Anoop N-
dc.contributor.authorVohra, Jitendra K-
dc.contributor.authorKalman, Jonathan M-
dc.contributor.authorSmith, Karen-
dc.contributor.authorO'Donnell, David-
dc.contributor.authorHare, David L-
dc.contributor.authorFarouque, Omar-
dc.contributor.authorLim, Han S-
dc.date2020-04-07-
dc.date.accessioned2020-04-14T04:00:53Z-
dc.date.available2020-04-14T04:00:53Z-
dc.date.issued2020-04-07-
dc.identifier.citationJournal of the American Heart Association 2020; 9(7): e015587en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/22918-
dc.description.abstractBackground The association between mitral valve prolapse (MVP) and sudden death remains controversial. We aimed to describe histopathological changes in individuals with autopsy-determined isolated MVP (iMVP) and sudden death and document cardiac arrest rhythm. Methods and Results The Australian National Coronial Information System database was used to identify cases of iMVP between 2000 and 2018. Histopathological changes in iMVP and sudden death were compared with 2 control cohorts matched for age, sex, height, and weight (1 group with noncardiac death and 1 group with cardiac death). Data linkage with ambulance services provided cardiac arrest rhythm for iMVP cases. From 77 221 cardiovascular deaths in the National Coronial Information System database, there were 376 cases with MVP. Individual case review yielded 71 cases of iMVP. Mean age was 49±18 years, and 51% were women. Individuals with iMVP had higher cardiac mass (447 g versus 355 g; P<0.001) compared with noncardiac death, but similar cardiac mass (447 g versus 438 g; P=0.64) compared with cardiac death. Individuals with iMVP had larger mitral valve annulus compared with noncardiac death (121 versus 108 mm; P<0.001) and cardiac death (121 versus 110 mm; P=0.002), and more left ventricular fibrosis (79% versus 38%; P<0.001) compared with noncardiac death controls. In those with iMVP and witnessed cardiac arrest, 94% had ventricular fibrillation. Conclusions Individuals with iMVP and sudden death have increased cardiac mass, mitral annulus size, and left ventricular fibrosis compared with a matched cohort, with cardiac arrest caused by ventricular fibrillation. The histopathological changes in iMVP may provide the substrate necessary for development of malignant ventricular arrhythmias.en_US
dc.language.isoeng-
dc.subjectsudden deathen_US
dc.subjectvalvular heart diseaseen_US
dc.subjectventricular arrhythmiaen_US
dc.titleCharacteristic Histopathological Findings and Cardiac Arrest Rhythm in Isolated Mitral Valve Prolapse and Sudden Cardiac Death.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of the American Heart Associationen_US
dc.identifier.affiliationDepartment of Forensic Medicine Victorian Institute of Forensic Medicine and Monash University Melbourne Victoria Australiaen_US
dc.identifier.affiliationAnatomical Pathologyen_US
dc.identifier.affiliationDepartment of Cardiology Western Health and University of Melbourne Melbourne Victoria Australiaen_US
dc.identifier.affiliationCardiologyen_US
dc.identifier.affiliationCentre for Heart Rhythm Disorders South Australian Health and Medical Research Institute University of Adelaide and Royal Adelaide Hospital Melbourne South Australia Australiaen_US
dc.identifier.affiliationUniversity of Melbourne Melbourne Victoria Australiaen_US
dc.identifier.affiliationDepartment of Cardiology Eastern Health and Monash University Melbourne Victoria Australiaen_US
dc.identifier.affiliationDepartment of Cardiology Northern Health and University of Melbourne Melbourne Victoria Australiaen_US
dc.identifier.affiliationCentre for Research and Evaluation Ambulance Victoria and Monash University Melbourne Victoria Australiaen_US
dc.identifier.affiliationDepartment of Cardiology Royal Melbourne Hospital and University of Melbourne Melbourne Victoria Australiaen_US
dc.identifier.affiliationDepartment of Cardiology and Department of Genomics Royal Melbourne Hospital and University of Melbourne Melbourne Victoria Australiaen_US
dc.identifier.doi10.1161/JAHA.119.015587en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0002-8741-8631en_US
dc.identifier.orcid0000-0001-9554-6556en_US
dc.identifier.pubmedid32233752-
dc.type.austinJournal Article-
local.name.researcherFarouque, Omar
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptCardiology-
crisitem.author.deptCardiology-
crisitem.author.deptCardiology-
crisitem.author.deptCardiology-
crisitem.author.deptCardiology-
crisitem.author.deptCardiology-
crisitem.author.deptCardiology-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

32
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.