Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/22849
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dc.contributor.authorAbbouchie, Hussein-
dc.contributor.authorChao, Michael-
dc.contributor.authorTacey, Mark A-
dc.contributor.authorLim Joon, Daryl-
dc.contributor.authorHo, Huong-
dc.contributor.authorGuerrieri, Mario-
dc.contributor.authorNg, Michael-
dc.contributor.authorForoudi, Farshad-
dc.date2020-03-15-
dc.date.accessioned2020-03-23T22:10:39Z-
dc.date.available2020-03-23T22:10:39Z-
dc.date.issued2020-04-01-
dc.identifier.citationJournal of Medical Imaging and Radiation Oncology 2020; 64(2): 293-302en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/22849-
dc.description.abstractStereotactic body radiotherapy has emerged as one of the preferred treatments for patients with spine metastases, with the potential for long-term control from lesion irradiation. Post-treatment vertebral compression fractures are a known complication of this therapy, contributing to worsening pain and reduced quality of life, sometimes requiring surgical intervention. This review explores the current knowledge of post-radiotherapy fractures, in terms of the rates and associated predictive factors. A search of databases including Medline, Embase and the Cochrane Library was conducted using keywords such as 'vertebral compression fracture', 'stereotactic body radiotherapy' and 'spine metastases'. The search was limited to published studies up to March 2019, reporting clinical outcomes including both the post-treatment fracture rate and statistical identification of associated risk factors. Rates of post-treatment fractures ranged from 4 to 39%. A variety of factors were found to increase the risk, including the appearance of lytic vertebral disease, degree of pre-existing compression, spinal malalignment, increased dose per fraction and a Spinal Instability Neoplastic Score >6. This knowledge can enable clinicians to counsel patients when considering management options for spine metastases, maintaining the balance between local tumour control and the risk of subsequent fracture.en_US
dc.language.isoeng-
dc.subjectcompression fracturesen_US
dc.subjectmetastasesen_US
dc.subjectspineen_US
dc.subjectstereotactic body radiotherapyen_US
dc.subjectstereotactic radiosurgeryen_US
dc.titleVertebral fractures following stereotactic body radiotherapy for spine metastases.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of Medical Imaging and Radiation Oncologyen_US
dc.identifier.affiliationUniversity of Melbourne, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationGenesis Cancer Care Melbourne Victoria Australiaen_US
dc.identifier.affiliationAustin Healthen_US
dc.identifier.affiliationOlivia Newton-John Cancer Research Instituteen_US
dc.identifier.doi10.1111/1754-9485.13010en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0002-7913-8584en_US
dc.identifier.orcid0000-0002-1947-9694en_US
dc.identifier.orcid0000-0002-3497-3746en_US
dc.identifier.orcid0000-0001-8387-0965en_US
dc.identifier.orcid0000-0002-6318-3911en_US
dc.identifier.orcid0000-0002-8212-4220en_US
dc.identifier.orcid0000-0003-3983-1752en_US
dc.identifier.pubmedid32174019-
dc.type.austinJournal Article-
local.name.researcherChao, Michael
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptRadiation Oncology-
crisitem.author.deptRadiation Oncology-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
crisitem.author.deptRadiation Oncology-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
crisitem.author.deptRadiation Oncology-
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