Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKorman, Ben-
dc.contributor.authorDash, Ranjan K-
dc.contributor.authorPeyton, Philip J-
dc.identifier.citationJournal of applied physiology 2020; 128(6): 1587-1593-
dc.description.abstractThe second gas effect occurs when high inspired concentrations of a first gas, usually nitrous oxide, enhance the uptake of other gases administered simultaneously. The second gas effect is greater in blood than in the gas phase; persists well into the period of nitrous oxide maintenance anesthesia; increases as the degree of ventilation-perfusion mismatch increases; and is most pronounced with the low soluble agents in current use. Yet, how low gas solubility and increased ventilation-perfusion mismatch can combine to improve gas transfer remains unclear, which is the focus of the present study. Specifically, we have used a two-step model of steady-state gas exchange to separate the effect of gas volume contraction, which accompanies the first gas uptake, from other factors. Step 1 involves the uptake of the second gas at constant volume. Contraction of gas volume takes place in step 2 and is most effective in transferring further amounts of gas to blood if the volume of second gas exposed to the contraction is maximized, i.e. if the loss of second gas in step 1 is minimized. Minimization depends on having a gas with a low solubility in blood and increases as the degree of ventilation-perfusion mismatch increases. The effectiveness of the contraction also requires a favorable alignment with the retained second gas. Alignment depends on the solubility of both gases and the degree of ventilation-perfusion mismatch. The model is fully consistent with the classical concepts of gas exchange.-
dc.subjectAnesthetic uptake-
dc.subjectMathematical modeling-
dc.subjectSecond gas effect-
dc.subjectVentilation-perfusion mismatch-
dc.titleElucidating the roles of solubility and ventilation-perfusion mismatch in the second gas effect using a two-step model of gas exchange.-
dc.typeJournal Article-
dc.identifier.journaltitleJournal of applied physiology-
dc.identifier.affiliationRoyal Perth Hospital-
dc.identifier.affiliationDepartment of Biomedical Engineering and Physiology, Medical College of Wisconsin, United States-
dc.identifier.affiliationDepartment of Anaesthesia, Austin Health, Heidelberg, Victoria, Australiaen
dc.type.austinJournal Article-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

checked on Sep 23, 2021

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.