Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/22712
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dc.contributor.authorOwen, Claire E-
dc.contributor.authorPoon, Aurora M T-
dc.contributor.authorYang, Victor-
dc.contributor.authorMcMaster, Christopher-
dc.contributor.authorLee, Sze Ting-
dc.contributor.authorLiew, David F L-
dc.contributor.authorLeung, Jessica L Y-
dc.contributor.authorScott, Andrew M-
dc.contributor.authorBuchanan, Russell R C-
dc.date2020-02-23-
dc.date.accessioned2020-03-02T03:28:03Z-
dc.date.available2020-03-02T03:28:03Z-
dc.date.issued2020-09-
dc.identifier.citationEuropean Journal of Nuclear Medicine and Molecular Imaging 2020; 47(10): 2461-2468-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/22712-
dc.description.abstractTo evaluate the sensitivity and specificity of PET/CT findings in PMR and generate a diagnostic algorithm utilizing a minimum number of musculoskeletal sites. Steroid-naïve patients with newly diagnosed PMR (2012 EULAR/ACR classification criteria) were prospectively recruited to undergo whole-body 18F-FDG PET/CT. Each PMR case was age- and sex-matched to four PET/CT controls. Control scan indication, diagnosis and medical history were extracted from the clinical record. Qualitative and semi-quantitative scoring (maximum standardized uptake value [SUVmax]) of abnormal 18F-FDG uptake at 21 musculoskeletal sites was undertaken for cases and controls. Results informed the development of a novel PET/CT diagnostic algorithm using a classification and regression trees (CART) method. Thirty-three cases met the inclusion criteria and were matched to 132 controls. Mean age was 68.6 ± 7.4 years for cases compared with 68.2 ± 7.3 for controls, and 54.5% were male. Median CRP was 49 mg/L (32-65) and ESR 41.5 mm/h (24.6-64.4) in the PMR group. The predominant control indication for PET/CT was malignancy (63.6%). Individual musculoskeletal sites proved insufficient for diagnostic purposes. A novel algorithm comprising 18F-FDG uptake ≥ 2 adjacent to the ischial tuberosities in combination with either abnormalities at the peri-articular shoulder or interspinous bursa achieved a sensitivity of 90.9% and specificity of 92.4% for diagnosing PMR. The presence of abnormal 18F-FDG uptake adjacent to the ischial tuberosities together with findings at the peri-articular shoulder or interspinous bursa on whole-body PET/CT is highly sensitive and specific for a diagnosis of PMR. Clinical Trial Registration: Australian New Zealand Clinical Trials Registry, http://www.anzctr.org.au, ACTRN1261400696695.-
dc.language.isoeng-
dc.subjectDiagnosis-
dc.subjectPolymyalgia rheumatica-
dc.subjectSensitivity-
dc.subjectSpecificity-
dc.subjectWhole-body positron emission tomography/computed tomography-
dc.titleAbnormalities at three musculoskeletal sites on whole-body positron emission tomography/computed tomography can diagnose polymyalgia rheumatica with high sensitivity and specificity.-
dc.typeJournal Articleen
dc.identifier.journaltitleEuropean Journal of Nuclear Medicine and Molecular Imaging-
dc.identifier.affiliationDepartment of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationSchool of Cancer Medicine, La Trobe University, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationOlivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDepartment of Rheumatology, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.doi10.1007/s00259-020-04731-z-
dc.type.contentTexten
dc.identifier.orcid0000-0002-2694-5411-
dc.identifier.orcid0000-0003-2432-5451-
dc.identifier.orcid0000-0001-8641-456X-
dc.identifier.orcid0000-0001-8451-8883-
dc.identifier.orcid0000-0002-6656-295X-
dc.identifier.pubmedid32090280-
dc.type.austinJournal Article-
local.name.researcherBuchanan, Russell R C
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptRheumatology-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptClinical Pharmacology and Therapeutics-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptRheumatology-
crisitem.author.deptClinical Pharmacology and Therapeutics-
crisitem.author.deptRheumatology-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
crisitem.author.deptRheumatology-
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