Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/22706
Full metadata record
DC FieldValueLanguage
dc.contributor.authorWilson, Danielle L-
dc.contributor.authorHoward, Mark E-
dc.contributor.authorFung, Alison M-
dc.contributor.authorO'Donoghue, Fergal J-
dc.contributor.authorBarnes, Maree-
dc.contributor.authorLappas, Martha-
dc.contributor.authorWalker, Susan P-
dc.date2020-02-26-
dc.date.accessioned2020-03-02T03:28:03Z-
dc.date.available2020-03-02T03:28:03Z-
dc.date.issued2020-02-26-
dc.identifier.citationPLoS One 2020; 15(2): e0229568en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/22706-
dc.description.abstractTo determine whether the presence of co-existing sleep-disordered breathing (SDB) is associated with worse perinatal outcomes among women diagnosed with a hypertensive disorder of pregnancy (HDP), compared with normotensive controls. Women diagnosed with HDP (gestational hypertension or preeclampsia) and BMI- and gestation-matched controls underwent polysomnography in late pregnancy to determine if they had coexisting SDB. Fetal heart rate (FHR) monitoring accompanied the sleep study, and third trimester fetal growth velocity was assessed using ultrasound. Cord blood was taken at delivery to measure key regulators of fetal growth. SDB was diagnosed in 52.5% of the HDP group (n = 40) and 38.1% of the control group (n = 42); p = .19. FHR decelerations were commonly observed during sleep, but the presence of SDB did not increase this risk in either the HDP or control group (HDP group-SDB = 35.3% vs. No SDB = 40.0%, p = 1.0; control group-SDB = 41.7% vs. No SDB = 25.0%, p = .44), nor did SDB affect the total number of decelerations overnight (HDP group-SDB = 2.7 ± 1.0 vs. No SDB = 2.8 ± 2.1, p = .94; control group-SDB = 2.0 ± 0.8 vs. No SDB = 2.0 ± 0.7, p = 1.0). Fetal growth restriction was the strongest predictor of fetal heart rate events during sleep (aOR 5.31 (95% CI 1.26-22.26), p = .02). The presence of SDB also did not adversely affect fetal growth; in fact among women with HDP, SDB was associated with significantly larger customised birthweight centiles (43.2% ± 38.3 vs. 16.2% ± 27.0, p = .015) and fewer growth restricted babies at birth (30% vs. 68.4%, p = .026) compared to HDP women without SDB. There was no impact of SDB on measures of fetal growth for the control group. Cord blood measures of fetal growth did not show any adverse effect among women with SDB, either in the HDP or control group. We did not find that the presence of mild SDB worsened fetal acute or longitudinal outcomes, either among women with HDP or BMI-matched normotensive controls. Unexpectedly, we found the presence of SDB conferred a better prognosis in HDP in terms of fetal growth. The fetus has considerable adaptive capacity to withstand in utero hypoxia, which may explain our mostly negative findings. In addition, SDB in this cohort was mostly mild. It may be that fetal sequelae will only be unmasked in the setting of more severe degrees of SDB and/or underlying placental disease.en_US
dc.language.isoeng-
dc.titleThe presence of coexisting sleep-disordered breathing among women with hypertensive disorders of pregnancy does not worsen perinatal outcome.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitlePLoS Oneen_US
dc.identifier.affiliationDepartment of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationInstitute for Breathing and Sleepen_US
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationMercy Hospital for Women, Heidelbergen_US
dc.identifier.doi10.1371/journal.pone.0229568en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0001-6754-7359en_US
dc.identifier.orcid0000-0002-4744-6929en_US
dc.identifier.orcid0000-0001-5099-3184en_US
dc.identifier.pubmedid32101584-
dc.type.austinJournal Article-
local.name.researcherBarnes, Maree
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptRespiratory and Sleep Medicine-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptInstitute for Breathing and Sleep-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

62
checked on Dec 23, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.