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https://ahro.austin.org.au/austinjspui/handle/1/22570
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Vaara, Suvi T | - |
dc.contributor.author | Ostermann, Marlies | - |
dc.contributor.author | Selander, Tuomas | - |
dc.contributor.author | Bitker, Laurent | - |
dc.contributor.author | Schneider, Antoine | - |
dc.contributor.author | Poli, Elettra | - |
dc.contributor.author | Hoste, Eric | - |
dc.contributor.author | Joannidis, Michael | - |
dc.contributor.author | Zarbock, Alexander | - |
dc.contributor.author | van Haren, Frank | - |
dc.contributor.author | Prowle, John | - |
dc.contributor.author | Pettilä, Ville | - |
dc.contributor.author | Bellomo, Rinaldo | - |
dc.date | 2020-02-05 | - |
dc.date.accessioned | 2020-02-11T01:18:16Z | - |
dc.date.available | 2020-02-11T01:18:16Z | - |
dc.date.issued | 2020-02-26 | - |
dc.identifier.citation | Acta Anaesthesiologica Scandinavica 2020; 64(6): 831-838 | - |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/22570 | - |
dc.description.abstract | Fluid accumulation frequently coexists with acute kidney injury (AKI) and is associated with increased risk for AKI progression and mortality. Among septic shock patients, restricted use of resuscitation fluid has been reported to reduce the risk of worsening of AKI. Restrictive fluid therapy, however, has not been studied in the setting of established AKI. Here, we present the protocol and statistical analysis plan of the REstricted fluid therapy VERsus Standard trEatment in Acute Kidney Injury - the REVERSE-AKI trial that compares a restrictive fluid therapy regimen to standard therapy in critically ill patients with AKI. REVERSE-AKI is an investigator-initiated, multinational, open-label, randomized, controlled, feasibility pilot trial conducted in 7 ICUs in 5 countries. We aim to randomize 100 critically ill patients with AKI to a restrictive fluid treatment regimen versus standard management. In the restrictive fluid therapy regimen, the daily fluid balance target is neutral or negative. The primary outcome is the cumulative fluid balance assessed after 72 hrs from randomization. Secondary outcomes include safety, feasibility, duration and severity of AKI, and outcome at 90 days (mortality and dialysis dependence). This is the first multinational trial investigating the feasibility and safety of a restrictive fluid therapy regimen in critically ill patients with AKI. | - |
dc.language.iso | eng | - |
dc.subject | acute kidney injury | - |
dc.subject | critically ill | - |
dc.subject | fluid balance | - |
dc.subject | restrictive fluid therapy | - |
dc.title | Protocol and statistical analysis plan for the REstricted fluid therapy VERsus Standard trEatment in Acute Kidney Injury - REVERSE-AKI randomized controlled pilot trial. | - |
dc.type | Journal Article | - |
dc.identifier.journaltitle | Acta Anaesthesiologica Scandinavica | - |
dc.identifier.affiliation | Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany | en |
dc.identifier.affiliation | Adult Intensive Care Unit, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland | en |
dc.identifier.affiliation | Critical Care and Preoperative Medicine Research Group, Centre for Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK | en |
dc.identifier.affiliation | Intensive Care Unit, Ghent University Hospital, Ghent University, Ghent, Belgium | en |
dc.identifier.affiliation | Université de Lyon, CREATIS CNRS UMR5220 INSERM U1044 INSA-Lyon, Lyon, France | en |
dc.identifier.affiliation | School of Medicine, The University of Melbourne, Melbourne, Australia | en |
dc.identifier.affiliation | King's College London, Guy's & St Thomas' Hospital, Department of Critical Care, London, UK | en |
dc.identifier.affiliation | Intensive Care Unit, Canberra Hospital, Canberra, Australia | en |
dc.identifier.affiliation | Australian National University Medical School, Canberra, Australia | en |
dc.identifier.affiliation | Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia | en |
dc.identifier.affiliation | Division of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland | en |
dc.identifier.affiliation | Science Service Center, Kuopio University Hospital, Kuopio, Finland.. | - |
dc.identifier.affiliation | Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University of Innsbruck, Austria.. | - |
dc.identifier.doi | 10.1111/aas.13557 | - |
dc.identifier.orcid | 0000-0002-3921-4423 | - |
dc.identifier.orcid | 0000-0002-1650-8939 | - |
dc.identifier.pubmedid | 32022904 | - |
dc.type.austin | Journal Article | - |
local.name.researcher | Bellomo, Rinaldo | |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
crisitem.author.dept | Intensive Care | - |
crisitem.author.dept | Data Analytics Research and Evaluation (DARE) Centre | - |
Appears in Collections: | Journal articles |
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