Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/22493
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dc.contributor.authorKrishnasamy, Rathika-
dc.contributor.authorHawley, Carmel M-
dc.contributor.authorJardine, Meg J-
dc.contributor.authorRoberts, Matthew A-
dc.contributor.authorCho, Yeoungjee-
dc.contributor.authorWong, Muhgeot-
dc.contributor.authorHeath, Anne-
dc.contributor.authorNelson, Craig L-
dc.contributor.authorSen, Shaundeep-
dc.contributor.authorMount, Peter F-
dc.contributor.authorPascoe, Elaine M-
dc.contributor.authorVergara, Liza A-
dc.contributor.authorPaul-Brent, Peta-Anne-
dc.contributor.authorToussaint, Nigel D-
dc.contributor.authorJohnson, David W-
dc.contributor.authorHutchison, Colin A-
dc.date2020-01-22-
dc.date.accessioned2020-01-29T02:51:26Z-
dc.date.available2020-01-29T02:51:26Z-
dc.date.issued2020-04-
dc.identifier.citationBlood Purification 2020en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/22493-
dc.description.abstractA new class of dialysis membrane, the mid cut-off (MCO) dialyzer, has been developed to improve the clearance of uremic toxins in hemodialysis (HD). The a tRial Evaluating Mid cut-Off Value membrane clearance of Albumin and Light chains in HemoDialysis patients (REMOVAL-HD) study aimed to determine if regular use of MCO dialyzer was safe and specifically did not result in a significant loss of albumin. This investigator initiated, crossover, longitudinal, device study was conducted across 9 centers in Australia and New Zealand (n = 89). Participants had a 4-week wash-in with high-flux HD, followed by 24-week intervention with MCO HD and a subsequent 4-week wash-out with high-flux HD. The primary outcome was change in serum albumin between weeks 4 and 28. Secondary outcomes included trends in serum albumin, changes in kappa- and lambda-free light chains (FLC), 6-min walk test (6MWT), malnutrition inflammation score (MIS), restless legs score and quality of life. Participants had a mean age of 66 ± 14 years, 62% were men, 45% were anuric, and 51% had -diabetes. There was no reduction in serum albumin following treatment with MCO HD (mean reduction -0.7 g/L, 95% CI -1.5 to 0.1). A sustained, unexplained reduction in serum albumin (>25%) was not observed in any participant. A reduction in FLC was observed 2 weeks into MCO HD (lambda-FLC: Δ -9.1 mg/L, 95% CI -14.4 to -3.7; kappa-FLC: Δ -5.7 mg/L, 95% CI -9.8 to -1.6) and was sustained for the rest of the study intervention. Both FLC increased after the cessation of MCO use. There was no improvement in restless legs symptoms, quality of life, 6MWT or MIS scores. Regular HD using the MCO dialyzer did not result in a significant fall in serum albumin. There were no effects on quality of life, functional status or nutrition. Australian New Zealand Clinical Trials Registry Number (ANZCTRN) 12616000804482.en_US
dc.language.isoeng-
dc.subjectAlbuminen_US
dc.subjectDialysis membraneen_US
dc.subjectDialyzeren_US
dc.subjectEfficacyen_US
dc.subjectFree light chainsen_US
dc.subjectHemodialysisen_US
dc.subjectMid cut-offen_US
dc.subjectSafetyen_US
dc.titleA tRial Evaluating Mid Cut-Off Value Membrane Clearance of Albumin and Light Chains in HemoDialysis Patients: A Safety Device Study.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleBlood Purificationen_US
dc.identifier.affiliationCenter for Kidney Disease Research, The University of Queensland, Brisbane, Queensland, Australiaen_US
dc.identifier.affiliationEastern Health Clinical School, Monash University, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Medicine, Hawke's Bay Hospital, Hawkes Bay, New Zealanden_US
dc.identifier.affiliationAustralasian Kidney Trials Network, The University of Queensland, Brisbane, Queensland, Australiaen_US
dc.identifier.affiliationDepartment of Nephrology, Sunshine Coast University Hospital, Birtinya, Queensland, Australiaen_US
dc.identifier.affiliationSan Renal Dialysis Unit, Sydney Adventist Hospital, Sydney, New South Wales, Australiaen_US
dc.identifier.affiliationThe George Institute for Global Health, UNSW, Sydney, New South Wales, Australiaen_US
dc.identifier.affiliationAustralasian Kidney Trials Network, The University of Queensland, Brisbane, Queensland, Australiaen_US
dc.identifier.affiliationCenter for Kidney Disease Research, The University of Queensland, Brisbane, Queensland, Australiaen_US
dc.identifier.affiliationDepartment of Nephrology, Princess Alexandra Hospital, Brisbane, Queensland, Australiaen_US
dc.identifier.affiliationDepartment of Nephrology, The Royal Melbourne Hospital, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Medicine (RMH), The University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationNephrologyen_US
dc.identifier.affiliationDepartment of Nephrology, Concord Repatriation and General Hospital, Sydney, New South Wales, Australiaen_US
dc.identifier.affiliationDepartment of Nephrology, Western Health, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Medicine, Western Health, University of Melbourne, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationWestern Health Chronic Disease Alliance, Western Centre for Health Research and Education, Western Health, St Albans, Victoria, Australiaen_US
dc.identifier.doi10.1159/000505567en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0001-7637-3661en_US
dc.identifier.pubmedid31968346-
dc.type.austinJournal Article-
local.name.researcherMount, Peter F
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptNephrology-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptMedicine (University of Melbourne)-
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