Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/22459
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dc.contributor.authorScheffer, Ingrid E-
dc.contributor.authorLiao, Jianxiang-
dc.date2019-12-31-
dc.date.accessioned2020-01-20T05:24:56Z-
dc.date.available2020-01-20T05:24:56Z-
dc.date.issued2020-01-
dc.identifier.citationEuropean journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 2020;24: 11-14-
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/22459-
dc.description.abstractThe recent introduction of the term 'developmental and epileptic encephalopathy' by the International League Against Epilepsy has added another conceptual layer to understanding the most severe group of epilepsies. An epileptic encephalopathy is defined by the presence of frequent epileptiform activity that impacts adversely on development, typically causing slowing or regression of developmental skills, and usually associated with frequent seizures. Many of the epileptic encephalopathies are now known to have an identifiable molecular genetic basis. The term 'developmental' was introduced as there are multiple facets leading to developmental impairment in affected individuals. The underlying genetic cause often results in developmental delay in its own right, with the epileptic encephalopathy further adversely affecting development. Treatment of the epileptic encephalopathy may improve developmental progress, so early recognition and active management are essential to improve developmental outcomes. Equally, understanding that the genetic aetiology independently leads to developmental impairment means that precision therapies need to be holistic in addressing the devastating consequences of this group of diseases.-
dc.language.isoeng-
dc.subjectDevelopmental and epileptic encephalopathy-
dc.subjectDevelopmental encephalopathy-
dc.subjectEpilepsy syndrome-
dc.subjectEpileptic encephalopathy-
dc.subjectRegression-
dc.titleDeciphering the concepts behind "Epileptic encephalopathy" and "Developmental and epileptic encephalopathy".-
dc.typeJournal Article-
dc.identifier.journaltitleEuropean journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society-
dc.identifier.affiliationDepartment of Medicine and Paediatrics, The University of Melbourne and Royal Children's Hospital, Florey Institute and Murdoch Children's Research Institute, Melbourne, Australiaen
dc.identifier.affiliationEpilepsy Center, Shenzhen Children's Hospital, Shenzhen, Guangdong Province, Chinaen
dc.identifier.affiliationDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDepartment of Paediatrics, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1016/j.ejpn.2019.12.023-
dc.identifier.orcid0000-0002-2311-2174-
dc.identifier.pubmedid31926847-
dc.type.austinJournal Article-
dc.type.austinReview-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptEpilepsy Research Centre-
Appears in Collections:Journal articles
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