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DC Field | Value | Language |
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dc.contributor.author | Scheffer, Ingrid E | - |
dc.contributor.author | Liao, Jianxiang | - |
dc.date | 2019-12-31 | - |
dc.date.accessioned | 2020-01-20T05:24:56Z | - |
dc.date.available | 2020-01-20T05:24:56Z | - |
dc.date.issued | 2020-01 | - |
dc.identifier.citation | European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 2020;24: 11-14 | - |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/22459 | - |
dc.description.abstract | The recent introduction of the term 'developmental and epileptic encephalopathy' by the International League Against Epilepsy has added another conceptual layer to understanding the most severe group of epilepsies. An epileptic encephalopathy is defined by the presence of frequent epileptiform activity that impacts adversely on development, typically causing slowing or regression of developmental skills, and usually associated with frequent seizures. Many of the epileptic encephalopathies are now known to have an identifiable molecular genetic basis. The term 'developmental' was introduced as there are multiple facets leading to developmental impairment in affected individuals. The underlying genetic cause often results in developmental delay in its own right, with the epileptic encephalopathy further adversely affecting development. Treatment of the epileptic encephalopathy may improve developmental progress, so early recognition and active management are essential to improve developmental outcomes. Equally, understanding that the genetic aetiology independently leads to developmental impairment means that precision therapies need to be holistic in addressing the devastating consequences of this group of diseases. | - |
dc.language.iso | eng | - |
dc.subject | Developmental and epileptic encephalopathy | - |
dc.subject | Developmental encephalopathy | - |
dc.subject | Epilepsy syndrome | - |
dc.subject | Epileptic encephalopathy | - |
dc.subject | Regression | - |
dc.title | Deciphering the concepts behind "Epileptic encephalopathy" and "Developmental and epileptic encephalopathy". | - |
dc.type | Journal Article | - |
dc.identifier.journaltitle | European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society | - |
dc.identifier.affiliation | Department of Medicine and Paediatrics, The University of Melbourne and Royal Children's Hospital, Florey Institute and Murdoch Children's Research Institute, Melbourne, Australia | en |
dc.identifier.affiliation | Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia | en |
dc.identifier.affiliation | Epilepsy Center, Shenzhen Children's Hospital, Shenzhen, Guangdong Province, China | en |
dc.identifier.affiliation | Department of Paediatrics, Austin Health, Heidelberg, Victoria, Australia | en |
dc.identifier.doi | 10.1016/j.ejpn.2019.12.023 | - |
dc.identifier.orcid | 0000-0002-2311-2174 | - |
dc.identifier.pubmedid | 31926847 | - |
dc.type.austin | Journal Article | - |
dc.type.austin | Review | - |
local.name.researcher | Scheffer, Ingrid E | |
item.grantfulltext | none | - |
item.openairetype | Journal Article | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Epilepsy Research Centre | - |
Appears in Collections: | Journal articles |
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