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https://ahro.austin.org.au/austinjspui/handle/1/22415
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DC Field | Value | Language |
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dc.contributor.author | Dang, Christa | - |
dc.contributor.author | Yassi, Nawaf | - |
dc.contributor.author | Harrington, Karra D | - |
dc.contributor.author | Xia, Ying | - |
dc.contributor.author | Lim, Yen Ying | - |
dc.contributor.author | Ames, David | - |
dc.contributor.author | Laws, Simon M | - |
dc.contributor.author | Hickey, Martha | - |
dc.contributor.author | Rainey-Smith, Stephanie | - |
dc.contributor.author | Sohrabi, Hamid R | - |
dc.contributor.author | Doecke, James D | - |
dc.contributor.author | Fripp, Jurgen | - |
dc.contributor.author | Salvado, Olivier | - |
dc.contributor.author | Snyder, Peter J | - |
dc.contributor.author | Weinborn, Michael | - |
dc.contributor.author | Villemagne, Victor L | - |
dc.contributor.author | Rowe, Christopher C | - |
dc.contributor.author | Masters, Colin L | - |
dc.contributor.author | Maruff, Paul | - |
dc.date | 2019-09-12 | - |
dc.date.accessioned | 2020-01-13T04:06:14Z | - |
dc.date.available | 2020-01-13T04:06:14Z | - |
dc.date.issued | 2019-12 | - |
dc.identifier.citation | Alzheimer's & dementia (Amsterdam, Netherlands) 2019; 11: 566-575 | en |
dc.identifier.issn | 2352-8729 | - |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/22415 | - |
dc.description.abstract | Superior cognitive performance in older adults may reflect underlying resistance to age-associated neurodegeneration. While elevated amyloid β (Aβ) deposition (Aβ+) has been associated with increased cortical atrophy, it remains unknown whether "SuperAgers" may be protected from Aβ-associated neurodegeneration. Neuropsychologically defined SuperAgers (n = 172) and cognitively normal for age (n = 172) older adults from the Australian Imaging, Biomarkers and Lifestyle study were case matched. Rates of cortical atrophy over 8 years were examined by SuperAger classification and Aβ status. Of the case-matched SuperAgers and cognitively normal for age older adults, 40.7% and 40.1%, respectively, were Aβ+. Rates of age- and Aβ-associated atrophy did not differ between the groups on any measure. Aβ- individuals displayed the slowest rates of atrophy. Maintenance of superior memory in late life does not reflect resistance to age- or Aβ-associated atrophy. However, those individuals who reached old age without cognitive impairment nor elevated Aβ deposition (i.e. Aβ-) displayed reduced rates of cortical atrophy. | en |
dc.language.iso | eng | - |
dc.subject | Aging | en |
dc.subject | Alzheimer's disease | en |
dc.subject | Memory | en |
dc.subject | Neurodegeneration | en |
dc.subject | β-amyloid | en |
dc.title | Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Alzheimer's & dementia (Amsterdam, Netherlands) | en |
dc.identifier.affiliation | National Ageing Research Institute, Parkville, Victoria, Australia | en |
dc.identifier.affiliation | Collaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia | en |
dc.identifier.affiliation | School of Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia | en |
dc.identifier.affiliation | Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia | en |
dc.identifier.affiliation | The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia | en |
dc.identifier.affiliation | CSIRO Health and Biosecurity, the Australian eHealth Research Centre, Brisbane, Queensland, Australia | en |
dc.identifier.affiliation | Cooperative Research Centre for Mental Health, Parkville, Victoria, Australia | en |
dc.identifier.affiliation | Department of Medicine and Neurology, Royal Melbourne Hospital, Melbourne, Victoria, Australia | en |
dc.identifier.affiliation | Department of Obstetrics and Gynaecology, Melbourne Medical School, The University of Melbourne, Parkville, Victoria, Australia | en |
dc.identifier.affiliation | Centre of Excellence for Alzheimer's Disease Research and Care, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia | en |
dc.identifier.affiliation | Australian Alzheimer's Disease Research Unit, Hollywood Private Hospital, Perth, Western Australia, Australia | en |
dc.identifier.affiliation | School of Psychological Science, University of Western Australia, Crawley, Western Australia, Australia | en |
dc.identifier.affiliation | School of Psychiatry and Clinical Neurosciences, University of Western Australia, Nedlands, Western Australia, Australia | en |
dc.identifier.affiliation | CogState Ltd., Melbourne, Victoria, Australia | en |
dc.identifier.affiliation | Department of Molecular Imaging & Therapy, Austin Health, Melbourne, Victoria, Australia | en |
dc.identifier.affiliation | Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia | en |
dc.identifier.affiliation | George & Anne Ryan Institute for Neuroscience, The University of Rhode Island, Kingston, RI, USA | en |
dc.identifier.doi | 10.1016/j.dadm.2019.05.005 | en |
dc.type.content | Text | en |
dc.identifier.orcid | 0000-0003-3910-2453 | en |
dc.identifier.pubmedid | 31909172 | - |
dc.type.austin | Journal Article | - |
local.name.researcher | Masters, Colin L | |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | Journal Article | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Molecular Imaging and Therapy | - |
crisitem.author.dept | Molecular Imaging and Therapy | - |
crisitem.author.dept | The Florey Institute of Neuroscience and Mental Health | - |
Appears in Collections: | Journal articles |
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