Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/22413
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dc.contributor.authorLibianto, Renata-
dc.contributor.authorDavis, Timothy Me-
dc.contributor.authorEkinci, Elif I-
dc.date2020-01-07-
dc.date.accessioned2020-01-13T04:06:14Z-
dc.date.available2020-01-13T04:06:14Z-
dc.date.issued2020-
dc.identifier.citationMedical Journal of Australia 2020; 212(3): 133-139en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/22413-
dc.description.abstractTreatment options for type 2 diabetes have expanded. While metformin remains the first line treatment in most cases, choices for second line treatment now extend beyond sulfonylureas and include the sodium-glucose cotransporter 2 (SGLT2) inhibitors, glucagon-like peptide 1 (GLP1) receptor agonists, and dipeptidyl peptidase 4 (DPP4) inhibitors. SGLT2 inhibitors are recommended for people with atherosclerotic cardiovascular disease, heart failure or kidney disease. Diabetic ketoacidosis is an uncommon but important side effect; its occurrence can be minimised with appropriate patient education and management, especially during perioperative periods and times of illness. GLP1 receptor agonists are recommended for people with atherosclerotic cardiovascular disease. Gastrointestinal side effects are common but are less prominent with the longer acting agents and can be minimised with slow titration of the shorter acting agents. DPP4 inhibitors are generally well tolerated, but alogliptin and saxagliptin should be used with caution in people with risk factors for heart failure. To optimise the management of type 2 diabetes, clinicians need to be aware of the pharmacological characteristics of each class of blood glucose-lowering medications and of the effect on cardiovascular health and renal function, balanced by potential adverse effects. Medications that have cardiovascular or renal benefits should be prescribed for patients with these comorbidities, and this is reflected in recent international guidelines.en_US
dc.language.isoeng-
dc.subjectCardiovascular agentsen_US
dc.subjectDiabetes mellitus, type 2en_US
dc.titleAdvances in type 2 diabetes therapy: a focus on cardiovascular and renal outcomes.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleMedical Journal of Australiaen_US
dc.identifier.affiliationUniversity of Western Australia, Perth, WAen_US
dc.identifier.affiliationMelbourne University, Melbourne, VICen_US
dc.identifier.affiliationAustin Healthen_US
dc.identifier.doi10.5694/mja2.50472en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0003-2372-395Xen_US
dc.identifier.pubmedid31910303-
dc.type.austinJournal Article-
dc.type.austinReview-
local.name.researcherEkinci, Elif I
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptEndocrinology-
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