Soliman, Caroline; Pier, Gerald B; Ramsland, Paul A

doi:10.1016/j.sbi.2019.12.001

Author(s)

Soliman, Caroline

Pier, Gerald B

Ramsland, Paul A

Publication Date

2019-12-21

Abstract

Because of the ongoing increase in antibiotic-resistant microbes, new strategies such as therapeutic antibodies and effective vaccines are required. Bacterial carbohydrates are known to be particularly antigenic, and several monoclonal antibodies that target bacterial polysaccharides have been generated, with more in current development. This review examines the known 3D crystal structures of anti-bacterial antibodies and the structural basis for carbohydrate recognition and explores the potential mechanisms for antibody-dependent bacterial cell death. Understanding the key interactions between an antibody and its polysaccharide target on the surface of bacteria or in biofilms can provide essential information for the development of more specific and effective antibody therapeutics as well as carbohydrate-based vaccines.

Citation

Current opinion in structural biology 2019; 62: 48-55

Jornal Title

Current opinion in structural biology

OrcId

0000-0002-2107-2738

Link

https://ahro.austin.org.au/austinjspui/handle/1/22313

Title

Antibody recognition of bacterial surfaces and extracellular polysaccharides.

Type of document

Journal Article

Austin Health

Antibody recognition of bacterial surfaces and extracellular polysaccharides.

Files:

Author(s)	Soliman, Caroline Pier, Gerald B Ramsland, Paul A
Publication Date	2019-12-21
Abstract	Because of the ongoing increase in antibiotic-resistant microbes, new strategies such as therapeutic antibodies and effective vaccines are required. Bacterial carbohydrates are known to be particularly antigenic, and several monoclonal antibodies that target bacterial polysaccharides have been generated, with more in current development. This review examines the known 3D crystal structures of anti-bacterial antibodies and the structural basis for carbohydrate recognition and explores the potential mechanisms for antibody-dependent bacterial cell death. Understanding the key interactions between an antibody and its polysaccharide target on the surface of bacteria or in biofilms can provide essential information for the development of more specific and effective antibody therapeutics as well as carbohydrate-based vaccines.
Citation	Current opinion in structural biology 2019; 62: 48-55
Jornal Title	Current opinion in structural biology
OrcId	0000-0002-2107-2738
Link	https://ahro.austin.org.au/austinjspui/handle/1/22313
Title	Antibody recognition of bacterial surfaces and extracellular polysaccharides.
Type of document	Journal Article