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Title: Antibody recognition of bacterial surfaces and extracellular polysaccharides.
Austin Authors: Soliman, Caroline;Pier, Gerald B;Ramsland, Paul A 
Affiliation: Department of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
School of Science, RMIT University, Melbourne, Victoria, Australia
Department of Immunology, Central Clinical School. Monash University, Melbourne, Victoria, Australia
Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, United States
Issue Date: 21-Dec-2019
Date: 2019-12-21
Publication information: Current opinion in structural biology 2019; 62: 48-55
Abstract: Because of the ongoing increase in antibiotic-resistant microbes, new strategies such as therapeutic antibodies and effective vaccines are required. Bacterial carbohydrates are known to be particularly antigenic, and several monoclonal antibodies that target bacterial polysaccharides have been generated, with more in current development. This review examines the known 3D crystal structures of anti-bacterial antibodies and the structural basis for carbohydrate recognition and explores the potential mechanisms for antibody-dependent bacterial cell death. Understanding the key interactions between an antibody and its polysaccharide target on the surface of bacteria or in biofilms can provide essential information for the development of more specific and effective antibody therapeutics as well as carbohydrate-based vaccines.
DOI: 10.1016/
ORCID: 0000-0002-2107-2738
Journal: Current opinion in structural biology
PubMed URL: 31874385
Type: Journal Article
Appears in Collections:Journal articles

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