Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/22279
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dc.contributor.authorYanes, Tatiane-
dc.contributor.authorMeiser, Bettina-
dc.contributor.authorKaur, Rajneesh-
dc.contributor.authorScheepers-Joynt, Maatje-
dc.contributor.authorMcInerny, Simone-
dc.contributor.authorTaylor, Shelby-
dc.contributor.authorBarlow-Stewart, Kristine-
dc.contributor.authorAntill, Yoland-
dc.contributor.authorSalmon, Lucinda-
dc.contributor.authorSmyth, Courtney-
dc.contributor.authorYoung, Mary-Anne-
dc.contributor.authorJames, Paul A-
dc.date2019-12-25-
dc.date.accessioned2019-12-18T04:02:52Z-
dc.date.available2019-12-18T04:02:52Z-
dc.date.issued2020-03-
dc.identifier.citationClinical genetics 2020; 97(3): 492-501-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/22279-
dc.description.abstractPolygenic risk scores (PRS) are increasingly being implemented to assess breast cancer risk. This study aimed to assess and determine factors associated with uptake of PRS among women at increased risk of breast cancer for whom genetic testing to date had been uninformative. Participants were recruited from the Variants in Practice study from which breast cancer PRS had been calculated. Four hundred women were notified by letter of the availability of their PRS and invited to complete a self-administered survey comprising several validated scales. Considering non-participants, uptake of PRS lies between 61.8% to 42.1%. Multivariate logistic regression identified that women were more likely to receive their PRS if they reported greater benefits (odds ratio [OR]=1.17, p=0.011) and fewer barriers to receiving their PRS (OR= 0.80, p=0.007), had completed higher level education (OR=3.32, p=0.004), and did not have daughters (0.29, p=0.006). Uptake of breast cancer PRS varies according to several testing- and patient-related factors. Knowledge of these factors will facilitate the implementation of polygenic testing in clinical practice and support informed decision making by patients. This article is protected by copyright. All rights reserved.-
dc.language.isoeng-
dc.subjectBreast cancer-
dc.subjectpolygenic risk-
dc.subjectpsychosocial-
dc.subjectsingle nucleotide polymorphism-
dc.subjectuptake-
dc.titleUptake of Polygenic Risk Information among Women at Increased Risk of Breast Cancer.-
dc.typeJournal Article-
dc.identifier.journaltitleClinical genetics-
dc.identifier.affiliationFamilial Cancer Clinic, Monash Medical Centre, Melbourne, Victoria, Australiaen
dc.identifier.affiliationParkville Familial Cancer Centre, Peter MacCallum Cancer Centre and the Royal Melbourne Hospital, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Clinical Genetics, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationFamilial Cancer Clinic, Cabrini Health, Melbourne, Victoria, Australiaen
dc.identifier.affiliationPrince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australiaen
dc.identifier.affiliationSchool of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australiaen
dc.identifier.affiliationSir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australiaen
dc.identifier.affiliationKinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Sydney, Australiaen
dc.identifier.affiliationNorthern Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australiaen
dc.identifier.doi10.1111/cge.13687-
dc.identifier.orcid0000-0002-3905-3025-
dc.identifier.pubmedid31833054-
dc.type.austinJournal Article-
local.name.researcherSalmon, Lucinda
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptClinical Genetics-
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