Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/22174
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dc.contributor.authorKaminski, Michelle R-
dc.contributor.authorLambert, Katrina A-
dc.contributor.authorRaspovic, Anita-
dc.contributor.authorMcMahon, Lawrence P-
dc.contributor.authorErbas, Bircan-
dc.contributor.authorMount, Peter F-
dc.contributor.authorKerr, Peter G-
dc.contributor.authorLandorf, Karl B-
dc.date2019-11-21-
dc.date.accessioned2019-12-04T04:59:39Z-
dc.date.available2019-12-04T04:59:39Z-
dc.date.issued2019-11-21-
dc.identifier.citationBMC Nephrology 2019; 20(1): 423en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/22174-
dc.description.abstractDialysis patients experience high rates of foot ulceration. Although risk factors for ulceration have been extensively studied in patients with diabetes, there is limited high-quality, longitudinal evidence in the dialysis population. Therefore, this study investigated risk factors for foot ulceration in a stable dialysis cohort. We prospectively collected clinical, demographic, health status, and foot examination information on 450 adults with end-stage renal disease from satellite and home-therapy dialysis units in Melbourne, Australia over 12 months. The primary outcome was foot ulceration. Cox proportional hazard modelling and multinomial regression were used to investigate risk factors. Among 450 dialysis patients (mean age, 67.5 years; 64.7% male; 94% hemodialysis; 50.2% diabetes), new cases of foot ulceration were identified in 81 (18%) participants. Overall, risk factors for foot ulceration were neuropathy (HR 3.02; 95% CI 1.48 to 6.15) and previous ulceration (HR 2.86; CI 1.53 to 5.34). In those without history of ulceration, nail pathology (RR 3.85; CI 1.08 to 13.75) and neuropathy (RR 2.66; CI 1.04 to 6.82) were risk factors. In those with history of ulceration, neuropathy (RR 11.23; CI 3.16 to 39.87), peripheral arterial disease (RR 7.15; CI 2.24 to 22.82) and cerebrovascular disease (RR 2.08; CI 1.04 to 4.16) were risk factors. There were 12 (2.7%) new amputations, 96 (21.3%) infections, 24 (5.3%) revascularizations, 42 (9.3%) foot-related hospitalizations, and 52 (11.6%) deaths. Neuropathy and previous ulceration are major risk factors for foot ulceration in dialysis patients. Risk factors differ between those with and without prior ulceration. The risk factors identified will help to reduce the incidence of ulceration and its associated complications.en_US
dc.language.isoeng-
dc.subjectAmputationen_US
dc.subjectChronic kidney failureen_US
dc.subjectDialysisen_US
dc.subjectFoot ulceren_US
dc.subjectRisk factorsen_US
dc.titleRisk factors for foot ulceration in adults with end-stage renal disease on dialysis: a prospective observational cohort study.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleBMC Nephrologyen_US
dc.identifier.affiliationDiscipline of Podiatry, School of Allied Health, Health Services and Sport, La Trobe University, Melbourne, Victoria, 3086, Australiaen_US
dc.identifier.affiliationNephrologyen_US
dc.identifier.affiliationDepartment of Public Health, School of Psychology and Public Health, La Trobe University, Victoria, 3086, Australiaen_US
dc.identifier.affiliationUniversity of Melbourne, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDiscipline of Podiatry, School of Allied Health, Health Services and Sport, La Trobe University, Melbourne, Victoria, 3086, Australiaen_US
dc.identifier.affiliationDepartments of Renal Medicine & Obstetric Medicine, Eastern Health Clinical School, Monash University, Melbourne, Victoria, 3128, Australiaen_US
dc.identifier.affiliationDepartment of Public Health, School of Psychology and Public Health, La Trobe University, Victoria, 3086, Australiaen_US
dc.identifier.affiliationDepartment of Nephrology, Monash Health, Melbourne, Victoria, 3168, Australiaen_US
dc.identifier.affiliationDiscipline of Podiatry, School of Allied Health, Health Services and Sport, La Trobe University, Melbourne, Victoria, 3086, Australiaen_US
dc.identifier.affiliationLa Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Health Services and Sport, La Trobe University, Victoria, 3086, Australiaen_US
dc.identifier.doi10.1186/s12882-019-1594-5en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0002-1133-4853en_US
dc.identifier.orcid0000-0001-7637-3661en_US
dc.identifier.pubmedid31752749-
dc.type.austinJournal Article-
local.name.researcherMount, Peter F
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptNephrology-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptMedicine (University of Melbourne)-
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