Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/22171
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dc.contributor.authorHata, Saori-
dc.contributor.authorOmori, Chiori-
dc.contributor.authorKimura, Ayano-
dc.contributor.authorSaito, Haruka-
dc.contributor.authorKimura, Nobuyuki-
dc.contributor.authorGupta, Veer-
dc.contributor.authorPedrini, Steve-
dc.contributor.authorHone, Eugene-
dc.contributor.authorChatterjee, Pratishtha-
dc.contributor.authorTaddei, Kevin-
dc.contributor.authorKasuga, Kensaku-
dc.contributor.authorIkeuchi, Takeshi-
dc.contributor.authorWaragai, Masaaki-
dc.contributor.authorNishimura, Masaki-
dc.contributor.authorHu, Anqi-
dc.contributor.authorNakaya, Tadashi-
dc.contributor.authorMeijer, Laurent-
dc.contributor.authorMaeda, Masahiro-
dc.contributor.authorYamamoto, Tohru-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorAmes, David-
dc.contributor.authorYamamoto, Kazuo-
dc.contributor.authorMartins, Ralph N-
dc.contributor.authorGandy, Sam-
dc.contributor.authorSuzuki, Toshiharu-
dc.date2019-11-07-
dc.date.accessioned2019-12-04T04:59:38Z-
dc.date.available2019-12-04T04:59:38Z-
dc.date.issued2019-11-07-
dc.identifier.citationAlzheimer's & dementia (New York, N. Y.) 2019; 5: 740-750-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/22171-
dc.description.abstractNeuronal p3-Alcβ peptides are generated from the precursor protein Alcadein β (Alcβ) through cleavage by α- and γ-secretases of the amyloid β (Aβ) protein precursor (APP). To reveal whether p3-Alcβ is involved in Alzheimer's disease (AD) contributes for the development of novel therapy and/or drug targets. We developed new sandwich enzyme-linked immunosorbent assay (sELISA) systems to quantitate levels of p3-Alcβ in the cerebrospinal fluid (CSF). In monkeys, CSF p3-Alcβ decreases with age, and the aging is also accompanied by decreased brain expression of Alcβ. In humans, CSF p3-Alcβ levels decrease to a greater extent in those with AD than in age-matched controls. Subjects carrying presenilin gene mutations show a significantly lower CSF p3-Alcβ level. A cell study with an inverse modulator of γ-secretase remarkably reduces the generation of p3-Alcβ37 while increasing the production of Aβ42. Aging decreases the generation of p3-Alcβ, and further significant decrease of p3-Alcβ caused by aberrant γ-secretase activity may accelerate pathogenesis in AD.-
dc.language.isoeng-
dc.subjectAftin-5-
dc.subjectAlcadein-
dc.subjectAlzheimer's disease-
dc.subjectAmyloid β-peptide-
dc.subjectCalsyntenin-
dc.subjectCerebrospinal fluid-
dc.subjectp3-Alc-
dc.subjectγ-secretase-
dc.titleDecrease in p3-Alcβ37 and p3-Alcβ40, products of Alcadein β generated by γ-secretase cleavages, in aged monkeys and patients with Alzheimer's disease.-
dc.typeJournal Article-
dc.identifier.journaltitleAlzheimer's & dementia (New York, N. Y.)-
dc.identifier.affiliationLaboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan-
dc.identifier.affiliationDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Japan-
dc.identifier.affiliationSection of Cell Biology and Pathology, Department of Alzheimer's Disease Research, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Japan-
dc.identifier.affiliationTsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba, Japan-
dc.identifier.affiliationCentre of Excellence for Alzheimer's Disease Research and Care, Sir James McCusker Alzheimer's Disease Research Unit, Edith Cowan University, Joodalup, WA, Australia-
dc.identifier.affiliationSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia-
dc.identifier.affiliationCo-operative Research Centre for Mental Health, Carlton, Victoria, Australia-
dc.identifier.affiliationDepartment of Biomedical Sciences, Faculty of Medical and Health Sciences, Macquarie University, Sydney, NSW, Australia-
dc.identifier.affiliationDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan-
dc.identifier.affiliationDepartment of Neurology, Higashi Matsudo Municipal Hospital, Matsudo, Japan-
dc.identifier.affiliationMolecular Neuroscience Research Center, Shiga University of Medical Science, Otsu, Japan-
dc.identifier.affiliationManRos Therapeutics, Centre de Perharidy, Roscoff, Bretagne, France-
dc.identifier.affiliationImmuno-Biological Laboratories Co., Ltd. (IBL), Fujioka, Japan-
dc.identifier.affiliationLaboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan-
dc.identifier.affiliationDepartment of Molecular Neurobiology, Faculty of Medicine, Kagawa University, Miki-cho, Kagawa, Japan-
dc.identifier.affiliationNeurodegeneration Division, The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia-
dc.identifier.affiliationDepartment of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia-
dc.identifier.affiliationNational Ageing Research Institute, Parkville, Victoria, Australia-
dc.identifier.affiliationAcademic Unit for Psychiatry of Old age, St. George's Hospital, The University of Melbourne, Parkville, Victoria, Australia-
dc.identifier.affiliationDepartment of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Japan-
dc.identifier.affiliationMount Sinai Center for Cognitive Health and NFL Neurological Care, Icahn School of Medicine at Mount Sinai, New York, NY, USA-
dc.identifier.doi10.1016/j.trci.2019.09.015-
dc.identifier.orcid0000-0003-3910-2453-
dc.identifier.pubmedid31754625-
dc.type.austinJournal Article-
local.name.researcherMasters, Colin L
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptMolecular Imaging and Therapy-
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