Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/22167
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDávalos-Salas, Mercedes-
dc.contributor.authorMontgomery, Magdalene K-
dc.contributor.authorReehorst, Camilla M-
dc.contributor.authorNightingale, Rebecca-
dc.contributor.authorNg, Irvin-
dc.contributor.authorAnderton, Holly-
dc.contributor.authorAl-Obaidi, Sheren-
dc.contributor.authorLesmana, Analia-
dc.contributor.authorScott, Cameron M-
dc.contributor.authorIoannidis, Paul-
dc.contributor.authorKalra, Hina-
dc.contributor.authorKeerthikumar, Shivakumar-
dc.contributor.authorTögel, Lars-
dc.contributor.authorRigopoulos, Angela-
dc.contributor.authorGong, Sylvia J-
dc.contributor.authorWilliams, David S-
dc.contributor.authorYoganantharaja, Prusoth-
dc.contributor.authorBell-Anderson, Kim-
dc.contributor.authorMathivanan, Suresh-
dc.contributor.authorGibert, Yann-
dc.contributor.authorHiebert, Scott-
dc.contributor.authorScott, Andrew M-
dc.contributor.authorWatt, Matthew J-
dc.contributor.authorMariadason, John M-
dc.date2019-
dc.date.accessioned2019-12-04T04:59:38Z-
dc.date.available2019-12-04T04:59:38Z-
dc.date.issued2019-11-22-
dc.identifier.citationNature Communications 2019; 10(1): 5291en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/22167-
dc.description.abstractHistone deacetylase 3 (Hdac3) regulates the expression of lipid metabolism genes in multiple tissues, however its role in regulating lipid metabolism in the intestinal epithelium is unknown. Here we demonstrate that intestine-specific deletion of Hdac3 (Hdac3IKO) protects mice from diet induced obesity. Intestinal epithelial cells (IECs) from Hdac3IKO mice display co-ordinate induction of genes and proteins involved in mitochondrial and peroxisomal β-oxidation, have an increased rate of fatty acid oxidation, and undergo marked remodelling of their lipidome, particularly a reduction in long chain triglycerides. Many HDAC3-regulated fatty oxidation genes are transcriptional targets of the PPAR family of nuclear receptors, Hdac3 deletion enhances their induction by PPAR-agonists, and pharmacological HDAC3 inhibition induces their expression in enterocytes. These findings establish a central role for HDAC3 in co-ordinating PPAR-regulated lipid oxidation in the intestinal epithelium, and identify intestinal HDAC3 as a potential therapeutic target for preventing obesity and related diseases.en
dc.language.isoeng-
dc.titleDeletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity.en
dc.typeJournal Articleen
dc.identifier.journaltitleNature Communicationsen
dc.identifier.affiliationOlivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationLa Trobe University School of Cancer Medicine, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Physiology, Faculty of Medicine Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationLa Trobe Institute for Molecular Sciences, La Trobe University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Pathology, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDepartment of Medicine, Deakin University, Geelong, Victoria, Australiaen
dc.identifier.affiliationFaculty of Science, Charles Perkins Centre, University of Sydney, Sydney, NSW, Australiaen
dc.identifier.affiliationVanderbilt University, Nashville, TN, USAen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationDepartment of Physiology, Faculty of Medicine Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.doi10.1038/s41467-019-13180-8en
dc.type.contentTexten
dc.identifier.orcid0000-0003-0692-5904en
dc.identifier.orcid0000-0002-8039-3582en
dc.identifier.orcid0000-0002-1357-4666en
dc.identifier.orcid0000-0003-3913-9686en
dc.identifier.orcid0000-0002-1003-7478en
dc.identifier.orcid0000-0003-0612-6440en
dc.identifier.orcid0000-0002-7761-3441en
dc.identifier.orcid0000-0002-7290-5795en
dc.identifier.orcid0000-0001-9123-7684en
dc.identifier.orcid0000-0002-6656-295Xen
dc.identifier.pubmedid31757939-
dc.type.austinJournal Article-
local.name.researcherMariadason, John M
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

36
checked on Jul 22, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.