Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/22119
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dc.contributor.authorHudson, Elizabeth P-
dc.contributor.authorCollie, Jake TB-
dc.contributor.authorFujii, Tomoko-
dc.contributor.authorLuethi, Nora-
dc.contributor.authorUdy, Andrew A-
dc.contributor.authorDoherty, Sarah-
dc.contributor.authorEastwood, Glenn-
dc.contributor.authorYanase, Fumitaka-
dc.contributor.authorNaorungroj, Thummaporn-
dc.contributor.authorBitker, Laurent-
dc.contributor.authorAbdelhamid, Yasmine Ali-
dc.contributor.authorGreaves, Ronda F-
dc.contributor.authorDeane, Adam M-
dc.contributor.authorBellomo, Rinaldo-
dc.date.accessioned2019-12-02T05:16:58Z-
dc.date.available2019-12-02T05:16:58Z-
dc.date.issued2019-12-
dc.identifier.citationCritical Care and Resuscitation 2019; 21(4): 236-42-
dc.identifier.issn1441-2772-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/22119-
dc.description.abstractTo study vitamin C pharmacokinetics in septic shock. Prospective pharmacokinetic study. Two intensive care units. Twenty-one patients with septic shock enrolled in a randomised trial of high dose vitamin C therapy in septic shock. Patients received 1.5 g intravenous vitamin C every 6 hours. Plasma samples were obtained before and at 1, 4 and 6 hours after drug administration, and vitamin C concentrations were measured by high performance liquid chromatography. Clearance, volume of distribution, and half-life were calculated using noncompartmental analysis. Data are presented as median (interquartile range [IQR]). Of the 11 participants who had plasma collected before any intravenous vitamin C administration, two (18%) were deficient (concentrations < 11 μmol/L) and three (27%) had hypovitaminosis C (concentrations between 11 and 23 μmol/L), with a median concentration 28 μmol/L (IQR, 11-44 μmol/L). Volume of distribution was 23.3 L (IQR, 21.9-27.8 L), clearance 5.2 L/h (IQR, 3.3-5.4 L/h), and half-life 4.3 h (IQR, 2.6-7.5 h). For the participants who had received at least one dose of intravenous vitamin C before sampling, T0 concentration was 258 μmol/L (IQR, 162- 301 μmol/L). Pharmacokinetic parameters for subsequent doses were a median volume of distribution 39.9 L (IQR, 31.4-44.4 L), clearance 3.6 L/h (IQR, 2.6-6.5 L/h), and half-life 6.9 h (IQR, 5.7-8.5 h). Intravenous vitamin C (1.5 g every 6 hours) corrects vitamin C deficiency and hypovitaminosis C and provides an appropriate dosing schedule to achieve and maintain normal or elevated vitamin C levels in septic shock.-
dc.language.isoeng-
dc.titlePharmacokinetic data support 6-hourly dosing of intravenous vitamin C to critically ill patients with septic shock.-
dc.typeJournal Article-
dc.identifier.journaltitleCritical Care and Resuscitation-
dc.identifier.affiliationMelbourne Medical School, University of Melbourne, Melbourne, VIC, Australia-
dc.identifier.affiliationSchool of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia-
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia-
dc.identifier.affiliationIntensive Care Unit, Royal Melbourne Hospital, Melbourne, VIC, Australia-
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia-
dc.identifier.affiliationDepartment of Intensive Care, Austin Health, Heidelberg, Victoria, Australia-
dc.identifier.affiliationMelbourne Medical School, University of Melbourne, Melbourne, VIC, Australia-
dc.identifier.affiliationSchool of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia-
dc.identifier.affiliationMelbourne Medical School, University of Melbourne, Melbourne, VIC, Australia-
dc.identifier.orcid0000-0002-1650-8939-
dc.identifier.pubmedid31778629-
dc.type.austinJournal Article-
local.name.researcherBellomo, Rinaldo
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.deptIntensive Care-
crisitem.author.deptIntensive Care-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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