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https://ahro.austin.org.au/austinjspui/handle/1/22119
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DC Field | Value | Language |
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dc.contributor.author | Hudson, Elizabeth P | - |
dc.contributor.author | Collie, Jake TB | - |
dc.contributor.author | Fujii, Tomoko | - |
dc.contributor.author | Luethi, Nora | - |
dc.contributor.author | Udy, Andrew A | - |
dc.contributor.author | Doherty, Sarah | - |
dc.contributor.author | Eastwood, Glenn | - |
dc.contributor.author | Yanase, Fumitaka | - |
dc.contributor.author | Naorungroj, Thummaporn | - |
dc.contributor.author | Bitker, Laurent | - |
dc.contributor.author | Abdelhamid, Yasmine Ali | - |
dc.contributor.author | Greaves, Ronda F | - |
dc.contributor.author | Deane, Adam M | - |
dc.contributor.author | Bellomo, Rinaldo | - |
dc.date.accessioned | 2019-12-02T05:16:58Z | - |
dc.date.available | 2019-12-02T05:16:58Z | - |
dc.date.issued | 2019-12 | - |
dc.identifier.citation | Critical Care and Resuscitation 2019; 21(4): 236-42 | - |
dc.identifier.issn | 1441-2772 | - |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/22119 | - |
dc.description.abstract | To study vitamin C pharmacokinetics in septic shock. Prospective pharmacokinetic study. Two intensive care units. Twenty-one patients with septic shock enrolled in a randomised trial of high dose vitamin C therapy in septic shock. Patients received 1.5 g intravenous vitamin C every 6 hours. Plasma samples were obtained before and at 1, 4 and 6 hours after drug administration, and vitamin C concentrations were measured by high performance liquid chromatography. Clearance, volume of distribution, and half-life were calculated using noncompartmental analysis. Data are presented as median (interquartile range [IQR]). Of the 11 participants who had plasma collected before any intravenous vitamin C administration, two (18%) were deficient (concentrations < 11 μmol/L) and three (27%) had hypovitaminosis C (concentrations between 11 and 23 μmol/L), with a median concentration 28 μmol/L (IQR, 11-44 μmol/L). Volume of distribution was 23.3 L (IQR, 21.9-27.8 L), clearance 5.2 L/h (IQR, 3.3-5.4 L/h), and half-life 4.3 h (IQR, 2.6-7.5 h). For the participants who had received at least one dose of intravenous vitamin C before sampling, T0 concentration was 258 μmol/L (IQR, 162- 301 μmol/L). Pharmacokinetic parameters for subsequent doses were a median volume of distribution 39.9 L (IQR, 31.4-44.4 L), clearance 3.6 L/h (IQR, 2.6-6.5 L/h), and half-life 6.9 h (IQR, 5.7-8.5 h). Intravenous vitamin C (1.5 g every 6 hours) corrects vitamin C deficiency and hypovitaminosis C and provides an appropriate dosing schedule to achieve and maintain normal or elevated vitamin C levels in septic shock. | - |
dc.language.iso | eng | - |
dc.title | Pharmacokinetic data support 6-hourly dosing of intravenous vitamin C to critically ill patients with septic shock. | - |
dc.type | Journal Article | - |
dc.identifier.journaltitle | Critical Care and Resuscitation | - |
dc.identifier.affiliation | Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia | - |
dc.identifier.affiliation | School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia | - |
dc.identifier.affiliation | Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia | - |
dc.identifier.affiliation | Intensive Care Unit, Royal Melbourne Hospital, Melbourne, VIC, Australia | - |
dc.identifier.affiliation | Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia | - |
dc.identifier.affiliation | Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia | - |
dc.identifier.affiliation | Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia | - |
dc.identifier.affiliation | School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia | - |
dc.identifier.affiliation | Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia | - |
dc.identifier.orcid | 0000-0002-1650-8939 | - |
dc.identifier.pubmedid | 31778629 | - |
dc.type.austin | Journal Article | - |
local.name.researcher | Bellomo, Rinaldo | |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Intensive Care | - |
crisitem.author.dept | Intensive Care | - |
crisitem.author.dept | Intensive Care | - |
crisitem.author.dept | Data Analytics Research and Evaluation (DARE) Centre | - |
Appears in Collections: | Journal articles |
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