Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/21825
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dc.contributor.authorCurrow, David-
dc.contributor.authorLouw, Sandra-
dc.contributor.authorMcCloud, Philip-
dc.contributor.authorFazekas, Belinda-
dc.contributor.authorPlummer, John-
dc.contributor.authorMcDonald, Christine F-
dc.contributor.authorAgar, Meera-
dc.contributor.authorClark, Katherine-
dc.contributor.authorMcCaffery, Nikki-
dc.contributor.authorEkström, Magnus Pär-
dc.date2019-09-26-
dc.date.accessioned2019-09-29T23:26:18Z-
dc.date.available2019-09-29T23:26:18Z-
dc.date.issued2020-01-
dc.identifier.citationThorax 2020; 75(1): 50-56en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/21825-
dc.description.abstractMorphine may decrease the intensity of chronic breathlessness but data from a large randomised controlled trial (RCT) are lacking. This first, large, parallel-group trial aimed to test the efficacy and safety of regular, low-dose, sustained-release (SR) morphine compared with placebo for chronic breathlessness. Multisite (14 inpatient and outpatient cardiorespiratory and palliative care services in Australia), parallel-arm, double-blind RCT. Adults with chronic breathlessness (modified Medical Research Council≥2) were randomised to 20 mg daily oral SR morphine and laxative (intervention) or placebo and placebo laxative (control) for 7 days. Both groups could take ≤6 doses of 2.5 mg, 'as needed', immediate-release morphine (≤15 mg/24 hours) as required by the ethics review board. The primary endpoint was change from baseline in intensity of breathlessness now (0-100 mm visual analogue scale; two times per day diary) between groups. Secondary endpoints included: worst, best and average breathlessness; unpleasantness of breathlessness now, fatigue; quality of life; function; and harms. Analysed by intention-to-treat, 284 participants were randomised to morphine (n=145) or placebo (n=139). There was no difference between arms for the primary endpoint (mean difference -0.15 mm (95% CI -4.59 to 4.29; p=0.95)), nor secondary endpoints. The placebo group used more doses of oral morphine solution during the treatment period (mean 8.7 vs 5.8 doses; p=0.001). The morphine group had more constipation and nausea/vomiting. There were no cases of respiratory depression nor obtundation. No differences were observed between arms for breathlessness, but the intervention arm used less rescue immediate-release morphine. ACTRN12609000806268.en_US
dc.language.isoeng-
dc.subjectchronic breathlessnessen_US
dc.subjectplacebo studyen_US
dc.subjectrandomised controlled trialen_US
dc.subjectsustained release morphineen_US
dc.subjectsymptom reliefen_US
dc.titleRegular, sustained-release morphine for chronic breathlessness: a multicentre, double-blind, randomised, placebo-controlled trial.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleThoraxen_US
dc.identifier.affiliationCollege of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australiaen_US
dc.identifier.affiliationNorthern Clinical School, University of Sydney, Sydney, New South Wales, Australiaen_US
dc.identifier.affiliationIMPACCT, Faculty of Heath, University of Technology Sydney, Sydney, New South Wales, Australiaen_US
dc.identifier.affiliationRespiratory and Sleep Medicineen_US
dc.identifier.affiliationUniversity of Melbourne, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationMcCloud Consulting Group, Sydney, New South Wales, Australiaen_US
dc.identifier.affiliationIMPACCT, Faculty of Heath, University of Technology Sydney, Sydney, New South Wales, Australiaen_US
dc.identifier.affiliationDepartment of Clinical Sciences, Division of Respiratory Medicine & Allergology, Lund University, Lund, Sweden..en_US
dc.identifier.affiliationCollege of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australiaen_US
dc.identifier.affiliationDeakin Health Economics, Deakin University Faculty of Health, Burwood, Victoria, Australiaen_US
dc.identifier.affiliationNorthern Sydney Local Health District, Saint Leonards, New South Wales, Australiaen_US
dc.identifier.doi10.1136/thoraxjnl-2019-213681en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0003-1988-1250en_US
dc.identifier.orcid0000-0001-6481-3391en_US
dc.identifier.pubmedid31558624-
dc.type.austinJournal Article-
local.name.researcherMcDonald, Christine F
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptRespiratory and Sleep Medicine-
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