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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/21750
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dc.contributor.authorXiong, Chengjie-
dc.contributor.authorLuo, Jingqin-
dc.contributor.authorAgboola, Folasade-
dc.contributor.authorLi, Yan-
dc.contributor.authorAlbert, Marilyn-
dc.contributor.authorJohnson, Sterling C-
dc.contributor.authorKoscik, Rebecca L-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorSoldan, Anja-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorLi, Qiao-Xin-
dc.contributor.authorMcDade, Eric M-
dc.contributor.authorFagan, Anne M-
dc.contributor.authorMassoumzadeh, Parinaz-
dc.contributor.authorBenzinger, Tammie-
dc.contributor.authorHassenstab, Jason-
dc.contributor.authorBateman, Randall J-
dc.contributor.authorMorris, John C-
dc.date2019-09-07-
dc.date.accessioned2019-09-16T04:32:24Z-
dc.date.available2019-09-16T04:32:24Z-
dc.date.issued2019-11-
dc.identifier.citationAlzheimer's & Dementia 2019; 15(11): 1448-1457en
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/21750-
dc.description.abstractLarge longitudinal biomarkers database focusing on middle age is needed for Alzheimer's disease (AD) prevention. Data for cerebrospinal fluid analytes, molecular imaging of cerebral fibrillar β-amyloid with positron emission tomography, magnetic resonance imaging-based brain structures, and clinical/cognitive outcomes were harmonized across eight AD biomarker studies. Statistical power was estimated. The harmonized database included 7779 participants with clinical/cognitive data: 3542 were 18∼65 years at the baseline, 5865 had longitudinal cognitive data for a median of 4.7 years, 2473 participated in the cerebrospinal fluid studies (906 had longitudinal data), 2496 participated in the magnetic resonance imaging studies (1283 had longitudinal data), and 1498 participated in the positron emission tomography amyloid studies (849 had longitudinal data). The database provides adequate power for detecting early biomarker changes, and demonstrates the feasibility of AD prevention trials on middle-aged individuals. The harmonized database is an optimum resource to design AD prevention trials decades before symptomatic onset.en
dc.language.isoeng-
dc.subjectAlzheimer diseaseen
dc.subjectAmyloid imaging with positron emission tomography (PET) using the [(11)C] benzothiazole traceren
dc.subjectBiomarkersen
dc.subjectCerebrospinal fluid (CSF)en
dc.subjectMagnetic resonance imaging (MRI) volumetricsen
dc.subjectPittsburgh Compound-B (PIB)en
dc.subjectPreclinical stagesen
dc.subjectPrevention trialsen
dc.titleA harmonized longitudinal biomarkers and cognition database for assessing the natural history of preclinical Alzheimer's disease from young adulthood and for designing prevention trials.en
dc.typeJournal Articleen
dc.identifier.journaltitleAlzheimer's & Dementiaen
dc.identifier.affiliationDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USAen
dc.identifier.affiliationDepartment of Radiology, Washington University School of Medicine, St. Louis, MO, USAen
dc.identifier.affiliationDepartments of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USAen
dc.identifier.affiliationThe Florey Institute, University of Melbourne, Melbourne, Australiaen
dc.identifier.affiliationDepartment of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Melbourne, Australiaen
dc.identifier.affiliationDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USAen
dc.identifier.affiliationKnight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USAen
dc.identifier.affiliationDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USAen
dc.identifier.affiliationSiteman Cancer Center Biostatistics Core Washington University School of Medicine, St. Louis, MO, USAen
dc.identifier.affiliationDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USAen
dc.identifier.affiliationWisconsin Alzheimer's Institute and Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USAen
dc.identifier.affiliationGeriatric Research Education and Clinical Center, William S Middleton Veterans Memorial Hospital, Madison, WI, USAen
dc.identifier.doi10.1016/j.jalz.2019.06.4955en
dc.type.contentTexten
dc.identifier.pubmedid31506247-
dc.type.austinJournal Article-
local.name.researcherMasters, Colin L
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptMolecular Imaging and Therapy-
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