Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/21738
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dc.contributor.authorBarnes, Hayley-
dc.contributor.authorGoh, Nicole S L-
dc.contributor.authorLeong, Tracy L-
dc.contributor.authorHoy, Ryan-
dc.date2019-09-13-
dc.date.accessioned2019-09-16T04:32:23Z-
dc.date.available2019-09-16T04:32:23Z-
dc.date.issued2019-12-
dc.identifier.citationRespirology 2019; 24(12): 1165-1175en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/21738-
dc.description.abstractDespite silica dust exposure being one of the earliest recognized causes of lung disease, Australia, USA, Israel, Turkey and other countries around the world have recently experienced significant outbreaks of silicosis. These outbreaks have occurred in modern industries such as denim jean production, domestic benchtop fabrication and jewellery polishing, where silica has been introduced without recognition and control of the hazard. Much of our understanding of silica-related lung disease is derived from traditional occupations such as mining, whereby workers may develop slowly progressive chronic silicosis. However, workers in modern industries are developing acute and accelerated silicosis over a short period of time, due to high-intensity silica concentrations, oxidative stress from freshly fractured silica and a rapid pro-inflammatory and pro-fibrotic response. Appropriate methods of screening and diagnosis remain unclear in these workers, and a significant proportion may go on to develop respiratory failure and death. There are no current effective treatments for silicosis. For those with near fatal respiratory failure, lung transplantation remains the only option. Strategies to reduce high-intensity silica dust exposure, enforced screening programmes and the identification of new treatments are urgently required.en_US
dc.language.isoeng-
dc.subjectinterstitial lung diseasesen_US
dc.subjectoccupational diseasesen_US
dc.subjectsilicon dioxideen_US
dc.subjectsilicosisen_US
dc.titleSilica-associated lung disease: An old-world exposure in modern industries.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleRespirologyen_US
dc.identifier.affiliationDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Respiratory Medicine, Alfred Hospital, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationRespiratory and Sleep Medicineen_US
dc.identifier.affiliationInstitute for Breathing and Sleepen_US
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Melbourne, Victoria, Australiaen_US
dc.identifier.doi10.1111/resp.13695en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0002-7615-4191en_US
dc.identifier.orcid0000-0003-2065-4346en_US
dc.identifier.orcid0000-0001-9150-9440en_US
dc.identifier.pubmedid31517432-
dc.type.austinJournal Article-
dc.type.austinReview-
local.name.researcherGoh, Nicole S L
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptRespiratory and Sleep Medicine-
crisitem.author.deptInstitute for Breathing and Sleep-
crisitem.author.deptRespiratory and Sleep Medicine-
crisitem.author.deptInstitute for Breathing and Sleep-
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