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dc.contributor.authorMohandas, Namitha-
dc.contributor.authorLoke, Yuk Jing-
dc.contributor.authorMackenzie, Lisa-
dc.contributor.authorBennett, Carmen-
dc.contributor.authorBerkovic, Samuel F-
dc.contributor.authorCraig, Jeffrey M-
dc.contributor.authorVadlamudi, Lata-
dc.identifier.citationEpilepsy research 2019; 156: 106163-
dc.description.abstractThe aetiology of self-limited epilepsy with centro-temporal spikes (SECTS) remains controversial and a strong genetic basis has long been presumed. The discordant monozygotic twin (MZ) model controls for shared genetic and environmental factors, enabling focus on the potential role of the non-shared environment. DNA methylation data was acquired from DNA extracted from three discordant MZ twin pairs, from both new born blood spots before epilepsy onset, and blood samples taken after epilepsy onset. An epigenome-wide analysis was performed, using the Illumina Infinium EPIC array. Differentially methylated regions (DMR) were identified using the bumphunter package in R. Comparative analyses were undertaken at the two different time points as well as a combined analysis independent of time. Many of the top DMR-associated genes have previously been described in neurodevelopmental disorders. The LYPD8 gene was associated with a top-ranked DMR both at birth and across the two time points. We have demonstrated the novel utility of the longitudinal, discordant MZ twin model, to facilitate a deeper appreciation of the complex neurobiology of SECTS. The genetic architecture of SECTS is complex and is likely to involve an interplay between genes and environment, in part mediated by epigenetics.-
dc.subjectMonozygotic twins-
dc.subjectSelf-limited epilepsy with centrotemporal spikes-
dc.titleDeciphering the role of epigenetics in self-limited epilepsy with centrotemporal spikes.-
dc.typeJournal Article-
dc.identifier.journaltitleEpilepsy research-
dc.identifier.affiliationCentre for Clinical Research, Faculty of Medicine, The University of Queensland, Queensland, Australiaen
dc.identifier.affiliationEpilepsy Research Centre, Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationRoyal Brisbane and Women's Hospital, Queensland, Australiaen
dc.identifier.affiliationCentre for Molecular and Medical Research, School of Medicine, Deakin University, Geelong, Victoria 3220, Australiaen
dc.identifier.affiliationDepartment of Paediatrics, University of Melbourne, Flemington Road, Parkville, Victoria, Australiaen
dc.identifier.affiliationEnvironmental & Genetic Epidemiology Research, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road, Parkville, Victoria, Australiaen
dc.type.austinJournal Article-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristype Research Centre-
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