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Title: Anatomical imaging of the piriform cortex in epilepsy.
Austin Authors: Young, James C;Vaughan, David N;Nasser, Helen M;Jackson, Graeme D 
Affiliation: The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia
Department of Neurology, Austin Health, Heidelberg, Victoria, Australia
ISN Psychology - Institute for Social Neuroscience, Unit 15, 443 Upper Heidelberg Rd, Ivanhoe, Victoria 3084, Australia
Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, 30 Royal Parade, Parkville, Victoria 3052, Australia
Issue Date: 16-Jul-2019 2019-07-16
Publication information: Experimental neurology 2019; 320: 113013
Abstract: The piriform cortex is a distinct brain region that plays a key role in the sense of smell. The piriform cortex is the major part of primary olfactory cortex and has broad connections that extend beyond the olfactory regions into limbic and fronto-temporal cortical networks. Numerous studies have described these anatomical connections via microscopic imaging and tracer studies. More recently, macroscopic anatomical imaging studies have demonstrated changes in the piriform cortex in humans with focal epilepsy as well as in animal models, suggesting this brain region can play a critical role in epileptogenesis. This review examines the imaging methods and techniques that have been most informative, leading to our current understanding of the anatomy and subdivsions of the piriform cortex as well as its connections to other brain structures, and the abnormalities that can be detected in the setting of epilepsy.
DOI: 10.1016/j.expneurol.2019.113013
ORCID: 0000-0002-6225-7739
Journal: Experimental neurology
PubMed URL: 31323251
Type: Journal Article
Subjects: Epilepsy
Piriform cortex
Appears in Collections:Journal articles

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