Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/21367
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dc.contributor.authorPapaluca, Timothy-
dc.contributor.authorSinclair, Marie-
dc.contributor.authorGow, Paul J-
dc.contributor.authorPianko, Stephen-
dc.contributor.authorSievert, William-
dc.contributor.authorArachchi, Niranjan-
dc.contributor.authorCameron, Karla-
dc.contributor.authorBowden, Scott-
dc.contributor.authorO'Keefe, Jacinta-
dc.contributor.authorDoyle, Joseph-
dc.contributor.authorStoove, Mark-
dc.contributor.authorHellard, Margaret-
dc.contributor.authorIser, David-
dc.contributor.authorThompson, Alexander-
dc.date2019-07-29-
dc.date.accessioned2019-08-12T05:00:01Z-
dc.date.available2019-08-12T05:00:01Z-
dc.date.issued2019-12-
dc.identifier.citationLiver International 2019; 39(12): 2285-2290en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/21367-
dc.description.abstractDespite highly effective direct-acting antiviral (DAA) therapies for chronic hepatitis C virus (HCV) infection, some patients experience virological relapse. Salvage regimens should include multiple agents to suppress emergence of resistance-associated substitutions (RAS) and minimise treatment failure. The combination of sofosbuvir (SOF) and elbasvir/grazoprevir (ELB/GZR) ±ribavirin (RBV) is an effective retreatment strategy for HCV genotype (GT)1 and 4 infection. We hypothesized that SOF and ELB/GZR (±RBV) would also be an effective salvage regimen for DAA-experienced GT3 patients. We evaluated the efficacy and safety of SOF/ELB/GZR±RBV in DAA-experienced participants with chronic HCV infection who had prior relapse. Participants were treated at four hospitals between December 2016 and March 2018 for either 12- or 16-weeks. The primary endpoint was sustained virological response at week 12 post-treatment (SVR12) using intention-to-treat analysis. There were 40 participants included in the analysis. The mean age was 53 years, 53% had GT3, 33% had GT1 infection, and 63% had cirrhosis. Fifty-eight percent were treated for 12 weeks, 42% were treated for 16 weeks, and 90% received RBV. The SVR12 rate was 98% overall, 100% in non-GT3 participants and 95% in GT3 participants. One GT3 cirrhotic participant relapsed. ELB/GZR was stopped at week 6 in one GT3 cirrhotic participant who switched to SOF/velpatasvir/RBV for a further 12 weeks and achieved SVR12. RBV dose reduction was required in two participants. Treatment was otherwise well tolerated. The combination of SOF/ELB/GZR±RBV is effective and safe for difficult-to-cure patients who relapse after first-line DAA, including those with cirrhosis and GT3 infection. This article is protected by copyright. All rights reserved.en_US
dc.language.isoeng-
dc.subjecthepatitis Cen_US
dc.subjectresistance associated substitutionen_US
dc.subjectretreatmenten_US
dc.subjectsalvageen_US
dc.subjectvirological relapseen_US
dc.titleRetreatment with Elbasvir, Grazoprevir, Sofosbuvir +/- Ribavirin is effective for GT3 and GT1/4/6 HCV infection after relapse.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleLiver Internationalen_US
dc.identifier.affiliationMonash Health and Monash University, Melbourne, Australiaen_US
dc.identifier.affiliationWestern Health, Melbourne, Australiaen_US
dc.identifier.affiliationSt Vincent's Hospital and the University of Melbourne, Australiaen_US
dc.identifier.affiliationAustin Healthen_US
dc.identifier.affiliationVictorian Infectious Disease Reference Laboratory, Melbourne, Australiaen_US
dc.identifier.affiliationDepartment of Infectious Diseases, The Alfred and Monash University, Melbourne, Australiaen_US
dc.identifier.affiliationBurnet Institute, Melbourne, Australiaen_US
dc.identifier.doi10.1111/liv.14201en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0003-0296-8624en_US
dc.identifier.pubmedid31355968-
dc.type.austinJournal Article-
local.name.researcherGow, Paul J
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
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