Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/20796
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dc.contributor.authorAbbott, Anne L-
dc.contributor.authorMerican, Julia-
dc.contributor.authorPearce, Dora C-
dc.contributor.authorJuric, Ana-
dc.contributor.authorWorsnop, Christopher J-
dc.contributor.authorFoster, Emma-
dc.contributor.authorChambers, Brian R-
dc.date2019-
dc.date.accessioned2019-05-17T00:25:33Z-
dc.date.available2019-05-17T00:25:33Z-
dc.date.issued2019-
dc.identifier.citationFrontiers in Neurology 2019;10:322en_US
dc.identifier.issn1664-2295-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/20796-
dc.description.abstractBackground and Purpose: Variability in transcranial Doppler (TCD) detection of embolic signals (ES) is important for risk stratification. We tested the effect of time of day on ES associated with 60-99% asymptomatic carotid stenosis. Materials and Methods: Subjects were from the Asymptomatic Carotid Stenosis Embolus Detection (ASED) Study such that half were previously ES-positive and half ES-negative with 6-monthly 60-min TCD monitoring. All underwent bilateral TCD monitoring for two 12-h sessions separated by 24 h. ES detection rates were calculated using 6 and 4-h intervals from midnight and effective TCD monitoring time. Results: Ten subjects (8 male, mean age 79.5 years) were monitored. Over 24 h, 5/10 study arteries with 60-99% asymptomatic carotid stenosis were ES-positive (range 1-28 ES/artery, 56 total ES from 177.9 total effective monitoring hours). The remaining five study arteries and all eight successfully monitored contralateral arteries were ES-negative. Using 6-h intervals the mean ES detection rate peaked at 0600-midday (0.64/h) and was lowest 1800-midnight (0.09/h) with an incidence rate ratio of 7.26 (95% CI 2.52-28.64, P ≤ 0.001). Using 4-h intervals the mean ES detection rate peaked at 0800-midday (0.64/h) and was lowest midnight-0400 (0.12/h) with an incidence rate ratio of 5.51 (95% CI 1.78-22.67, P = 0.001). Conclusions: Embolism associated with asymptomatic carotid stenosis shows circadian variation with highest rates 4-6 h before midday. This corresponds with peak circadian incidence of stroke and other vascular complications. These and ASED Study results show that monitoring frequency, duration, and time of day are important in ES detection.en_US
dc.language.isoeng-
dc.subjectcarotid stenosisen_US
dc.subjectcircadianen_US
dc.subjectembolismen_US
dc.subjectsleep apneaen_US
dc.subjectStrokeen_US
dc.subjecttranscranial Doppleren_US
dc.titleAsymptomatic Carotid Stenosis Is Associated With Circadian and Other Variability in Embolus Detection.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleFrontiers in Neurologyen_US
dc.identifier.affiliationRespiratory and Sleep Medicineen_US
dc.identifier.affiliationSchool of Science, Engineering and Information Technology, Federation University, Ballarart, Victoria, Australiaen_US
dc.identifier.affiliationIndependent Researcher, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationCentral Clinical School, Monash University, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationNeurology Department, Alfred Health, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationNeurology Department, The Royal Melbourne Hospital, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationNeurologyen_US
dc.identifier.affiliationFaculty of Medicine, University of Melbourne, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationNeurology Network, Knox Private Hospital, Wantirna, Victoria, Australiaen_US
dc.identifier.affiliationNeurology and Neurosurgery Centre, Princecourt Medical Centre, Kuala Lumpur, Malaysiaen_US
dc.identifier.affiliationFaculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australiaen_US
dc.identifier.doi10.3389/fneur.2019.00322en_US
dc.type.contentTexten_US
dc.identifier.pubmedid31040812-
dc.type.austinJournal Article-
local.name.researcherChambers, Brian R
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptRespiratory and Sleep Medicine-
crisitem.author.deptNeurology-
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