Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/20731
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Ng, Zi Yun | - |
dc.contributor.author | Bishton, Mark | - |
dc.contributor.author | Ritchie, David | - |
dc.contributor.author | Campbell, Robert | - |
dc.contributor.author | Gilbertson, Michael | - |
dc.contributor.author | Hill, Kate | - |
dc.contributor.author | Ratnasingam, Sumita | - |
dc.contributor.author | Schwarer, Anthony | - |
dc.contributor.author | Manos, Kate | - |
dc.contributor.author | Shorten, Sophie | - |
dc.contributor.author | Ng, Melissa | - |
dc.contributor.author | Nelson, Niles | - |
dc.contributor.author | Xin, Liu | - |
dc.contributor.author | De Mel Widanalage, Sanjay | - |
dc.contributor.author | Sunny, Tenny | - |
dc.contributor.author | Purtill, Duncan | - |
dc.contributor.author | Poon, Michelle | - |
dc.contributor.author | Johnston, Anna | - |
dc.contributor.author | Cochrane, Tara | - |
dc.contributor.author | Lee, Hui-Peng | - |
dc.contributor.author | Hapgood, Greg | - |
dc.contributor.author | Tam, Constantine | - |
dc.contributor.author | Opat, Stephen | - |
dc.contributor.author | Hawkes, Eliza | - |
dc.contributor.author | Seymour, John | - |
dc.contributor.author | Cheah, Chan Yoon | - |
dc.date | 2019-04-15 | - |
dc.date.accessioned | 2019-04-30T23:55:29Z | - |
dc.date.available | 2019-04-30T23:55:29Z | - |
dc.date.issued | 2019-08 | - |
dc.identifier.citation | Hematological oncology 2019; 37(3): 253-260 | - |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/20731 | - |
dc.description.abstract | Mantle cell lymphoma (MCL) is an uncommon and typically aggressive form of lymphoma. Although often initially chemosensitive, relapse is common. Several induction and conditioning regimens are used in transplant eligible patients and the optimal approach remains unknown. We performed an international, retrospective study of transplant eligible patients to assess impact of induction chemo-immunotherapy and conditioning regimens on clinical outcomes. We identified 228 patients meeting inclusion criteria. Baseline characteristics were similar among the induction groups except for some variation in age. The type of induction chemo-immunotherapy received did not influence overall response rates (ORR) (0.43), progression free survival (PFS) (P>0.67) or overall survival (OS) (P>0.35) on multivariate analysis (PFS and OS). Delivery of ASCT was associated with favourable PFS and OS (0.01) on univariate analysis only; this benefit was not seen on multivariate analysis - PFS (0.36) and OS (0.21). Compared with BuMel (busulfan and melphalan), the use of the BEAM (carmustine, etoposide, cytarabine, melphalan) conditioning regimen was associated with inferior PFS (HR=2.0 [95%CI 1.1-3.6], 0.02) but not OS (HR=1.1 [95%CI 0.5-2.3] 0.81) on univariate analysis only. Within the limits of a retrospective study and modest power for some comparisons, type of induction therapy did not influence ORR, PFS or OS for transplant eligible patients with MCL. International efforts are required to perform randomized clinical trials evaluating chemo-immunotherapy induction regimens. | - |
dc.language.iso | eng | - |
dc.subject | Autologous Stem Cell Transplant | - |
dc.subject | Conditioning | - |
dc.subject | Induction | - |
dc.subject | Mantle Cell Lymphoma | - |
dc.title | A Multi-Center Retrospective Comparison of Induction Chemoimmunotherapy Regimens on Outcomes in Transplant-eligible Patients with Previously Untreated Mantle Cell Lymphoma. | - |
dc.type | Journal Article | - |
dc.identifier.journaltitle | Hematological oncology | - |
dc.identifier.affiliation | Department of Haematology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia | - |
dc.identifier.affiliation | Department of Haematology, Royal Melbourne Hospital & Peter MacCallum Cancer Centre, and University of Melbourne, Melbourne, Victoria, Australia | en |
dc.identifier.affiliation | Department of Medical Oncology, Eastern Health, Box Hill, Victoria, Australia | en |
dc.identifier.affiliation | Department of Medical Oncology and Clinical Haematology, Olivia Newton-John Cancer Research and Wellness Centre, Austin Health, Heidelberg, Victoria, Australia | en |
dc.identifier.affiliation | Medical School, University of Western Australia, Crawley, Western Australia, Australia | en |
dc.identifier.affiliation | Department of Haematology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia | en |
dc.identifier.affiliation | Department of Haematology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom | - |
dc.identifier.affiliation | Department of Haematology, St Vincent's Hospital, Fitzroy, Victoria, Australia | en |
dc.identifier.affiliation | Department of Haematology, Royal Melbourne Hospital & Peter MacCallum Cancer Centre, and University of Melbourne, Melbourne, Victoria, Australia | - |
dc.identifier.affiliation | Department of Medical Oncology, Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Victoria, Australia | - |
dc.identifier.affiliation | Clinical Haematology, Monash Health and Monash University, Clayton, Victoria, Australia | - |
dc.identifier.affiliation | Cancer Care Services, Princess Alexandra Hospital, Brisbane, Queensland, Australia | - |
dc.identifier.affiliation | Clinical Haematology, Monash Health and Monash University, Clayton, Victoria, Australia | - |
dc.identifier.affiliation | Department of Medical Oncology, Eastern Health, Box Hill, Victoria, Australia | - |
dc.identifier.affiliation | Department of Haematology, Flinders Medical Centre, Bedford Park, South Australia, Australia | - |
dc.identifier.affiliation | Department of Haematology, St Vincent's Hospital, Fitzroy, Victoria, Australia | - |
dc.identifier.affiliation | Department of Haematology, Gold Coast University Hospital, Southport, Queensland, Australia | - |
dc.identifier.affiliation | Department of Haematology, Royal Hobart Hospital, Hobart, Tasmania, Australia | - |
dc.identifier.affiliation | Department of Haematology-Oncology, National University Cancer Institute Singapore, National University Health System, Singapore | - |
dc.identifier.affiliation | Department of Haematology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia | - |
dc.identifier.affiliation | Department of Haematology-Oncology, National University Cancer Institute Singapore, National University Health System, Singapore | - |
dc.identifier.affiliation | Department of Haematology, Royal Hobart Hospital, Hobart, Tasmania, Australia | - |
dc.identifier.affiliation | Department of Haematology, Gold Coast University Hospital, Southport, Queensland, Australia | - |
dc.identifier.affiliation | Department of Haematology, Flinders Medical Centre, Bedford Park, South Australia, Australia | - |
dc.identifier.affiliation | Cancer Care Services, Princess Alexandra Hospital, Brisbane, Queensland, Australia | - |
dc.identifier.affiliation | Clinical Haematology, Monash Health and Monash University, Clayton, Victoria, Australia | - |
dc.identifier.affiliation | Department of Haematology, Royal Melbourne Hospital & Peter MacCallum Cancer Centre, and University of Melbourne, Melbourne, Victoria, Australia | - |
dc.identifier.affiliation | Department of Clinical Haematology, Austin Health, Heidelberg, Victoria, Australia | - |
dc.identifier.doi | 10.1002/hon.2618 | - |
dc.identifier.orcid | 0000-0001-5050-1223 | en |
dc.identifier.orcid | 0000-0001-7988-1565 | en |
dc.identifier.pubmedid | 30983008 | - |
dc.type.austin | Journal Article | - |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | Journal Article | - |
Appears in Collections: | Journal articles |
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